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19.12.2023

GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners

Authors Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 19:gkad1202. Abstract Regulation of RNA helicase activity, often accomplished by protein cofactors, is
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19.12.2023

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell

Authors Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2023 Dec 19:100704. Abstract In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory
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15.12.2023

Implications for neutrophils in cardiac arrhythmias

Authors Hegemann N, Barth L, Doering Y, Voigt N, Grune J Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2023 Dec 15. Abstract Cardiac arrhythmias commonly occur as a result of aberrant electrical impulse formation or conduction in the myocardium. Frequently discussed
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12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
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11.12.2023

Protein nanobarcodes enable single-step multiplexed fluorescence imaging

Authors de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO Journal PLoS Biology Citation PLoS Biol. 2023 Dec 11;21(12):e3002427. Abstract Multiplexed cellular imaging typically relies on the sequential application of detection probes, as antibodies or DNA
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08.12.2023

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

Authors Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C Journal iScience Citation iScience. 2023 Dec 8;27(1):108700. Abstract Mitochondria are key organelles to provide ATP for synaptic transmission. This study aims to unravel the structural adaptation of mitochondria to an increase in presynaptic energy demand
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08.12.2023

Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Authors Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T Journal Protein & Cell Citation Protein & Cell. 2023 Dec 8:pwad058. accepted manuscript.
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07.12.2023

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Authors Kyriakopoulou E, Versteeg D, de Ruiter H, Perini I, Seibertz F, Döring Y, Zentilin L, Tsui H, van Kampen S, Tiburcy M, Meyer T, Voigt N, van Tintelen J, Zimmermann W, Giacca M, van Rooij E Journal Nature Cardiovascular Research Citation Nat Cardiovasc Res 2, 1262–1276 (2023 Dec 07)
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07.12.2023

Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing

Authors Schreiber MK, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2023 Dec 7;74:103276. Abstract Genetic alterations in the PLP1 gene, i.e. point mutations and duplications, are associated with demyelinating disease Pelizaeus-Merzbacher. Here, we describe the generation of a human iPSC line harboring a PLP1 variant in codon
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05.12.2023

The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro

Authors Wicke D, Neumann P, Gößringer M, Chernev A, Davydov S, Poehlein A, Daniel R, Urlaub H, Hartmann RK, Ficner R, Stülke J Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 5:gkad1171. Abstract Even though Bacillus subtilis is one of the most studied organisms, no function has been
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