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22.06.2024

Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

Authors Outeiro TF, Brocardo PS, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2024 Jun 22. Abstract Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network.
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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18.06.2024

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Authors Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt
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12.06.2024

X-ray phase-contrast tomography of cells manipulated with an optical stretcher

Authors Burchert JP, Frohn J, Rölleke U, Bruns H, Yu B, Gleber SC, Stange R, Busse M, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2024 Jul 1. Abstract X-rays can penetrate deeply into biological cells and thus allow for examination of their
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10.06.2024

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

Authors Capel RA, Akerman E, Rog-Zielinska E, Winbo A, Aston D, Mu-u-min RBA, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Montgomery JM, Falter F, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto J, Sharma P, Song
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07.06.2024

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK Journal Science Advances Citation Sci Adv. 2024 Jun 7;10(23):eadn7191. Abstract Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a
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06.06.2024

Open Problem: Active Representation Learning

Authors Milosevic N, Müller G, Huisken J, Scherf N Journal Arxiv Citation arXiv:2406.03845. Abstract In this work, we introduce the concept of Active Representation Learning, a novel class of problems that intertwines exploration and representation learning within partially observable environments. We extend ideas from Active Simultaneous Localization and Mapping (active
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04.06.2024

Effective exosomes reduction in hypercholesterinemic patients suffering from cardiovascular diseases by lipoprotein apheresis: Exosomes apheresis

Authors Schröder S, Epple R, Fischer A, Schettler VJJ Journal Therapeutic Apheresis and Dialysis Citation Ther Apher Dial. 2024 Jun 4. Abstract Introduction: Extracellular vesicles (EVs) have been identified as playing a role in atherosclerosis. Methods: A group of 37 hypercholesterolemic patients with atherosclerotic cardiovascular diseases (ASCVD) and 9 patients
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03.06.2024

The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice

Authors Edelman BJ, Siegenthaler D, Wanken P, Jenkins B, Schmid B, Ressle A, Gogolla N, Frank T, Macé E Journal Plos Biology Citation PLOS Biology 22(6): e3002664. Abstract Neuroscientists studying the neural correlates of mouse behavior often lack access to the brain-wide activity patterns elicited during a specific task of
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03.06.2024

Catching up but still miles behind — a patient registry for otoferlin

Authors Vona B, Wollnik B, Strenzke N, Moser T Journal Experimental & Molecular Medicine Citation Exp Mol Med (2024). Abstract No abstract available. DOI 10.1038/s12276-024-01247-6   Pubmed Link
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