Proceedings of the National Academy of Sciences of the United States of America

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03.04.2024

Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion

Authors López-Murcia FJ, Lin KH, Berns MMM, Ranjan M, Lipstein N, Neher E, Brose N, Reim K, Taschenberger H   Journal Proceedings of the National Academy of Sciences of the United States of America   Citation Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320505121.   Abstract The presynaptic
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09.01.2024

Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid

Authors Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE Journal Proceedings of the National Academy of Sciences of the United
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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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24.10.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J. Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2305460120. Abstract Pre- and postsynaptic forms of long-term potentiation
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04.04.2023

Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain

Authors Schilbach S, Wang H, Dienemann C, Cramer P Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2220542120. Abstract For transcription initiation, RNA polymerase II (Pol II) forms a preinitiation complex (PIC) that associates with the general coactivator Mediator. Whereas
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22.02.2023

Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts

Authors Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Sakib MS, Burkhart S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2204933120. Abstract N6-methyladenosine (m6A) regulates mRNA
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04.01.2023

Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome

Authors Akol I, Izzo A, Gather F, Strack S, Heidrich S, Ó hAilín D, Villarreal A, Hacker C, Rauleac T, Bella C, Fischer A, Manke T, Vogel T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A.
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27.12.2022

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Authors Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. Abstract Capturing mitochondria’s intricate and dynamic
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09.08.2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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13.07.2022

A Sequential Two-Step Priming Scheme Reproduces Diversity in Synaptic Strength and Short-Term Plasticity

Authors Lin KH, Taschenberger H, Neher E Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207987119. Abstract Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional
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