2025

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15.10.2025

Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation

Authors Pronto JRD, Mason FE, Rog-Zielinska EA, Fakuade FE, Bülow D, Tóth M, Machwart K, Brandes P, Wiedmann F, Kohlhaas M, Nickel A, Wolf M, Mustroph J, Vu KC, Brandenburg S, Do TQ, Siedler PJ, Ritzenhoff K, Xue Z, Zhou X, Kestel S, Dschun O, Kyshynska O, Kensah G, Rebbeck
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13.10.2025

Peroxisome protein import deficiency causes heart failure in mouse and human

Authors Hofhuis J, Tiburcy M, Hartmann Y, Bersch K, Wagdi A, Gutiérrez-Gutiérrez O, Solano R, Thiele L, Walper M, Göbel M, Hübner W, Berecic B, Casini M, Tirilomis P, Unger A, Lipstein N, Sossalla S, Huser T, Streckfuss-Bömeke K, Elkenani M, Toischer K, Kohlhaas M, Dudek J, Zimmermann WH, Voigt
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08.10.2025

Expected and Unexpected „Guests“ at the Active Site of Human Orotidine 5′-Monophosphate Decarboxylase

Authors Kirck LL, Santagostino E, Brandhoff L, Simeth NA, Tittmann K Journal Biochemistry Citation Biochemistry. 2025 Oct 8. Abstract With an extraordinary rate enhancement of 1017 compared to the uncatalyzed reaction and no need for a cofactor, orotidine 5′-monophosphate decarboxylase (OMPDC) is considered one of the most efficient enzymes. Its
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07.10.2025

Weak convergence of Bayes estimators under general loss functions

Authors Requadt R, Li H, Munk A Journal Arxiv Citation arXiv:2510.05645. Abstract We investigate the asymptotic behavior of parametric Bayes estimators under a broad class of loss functions that extend beyond the classical translation-invariant setting. To this end, we develop a unified theoretical framework for loss functions exhibiting locally polynomial
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07.10.2025

Mapping complex optical light field distributions with single fluorescent molecules

Authors Marx D, Gligonov I, Malsbenden D, Wöll D, Nevskyi O, Enderlein J Journal Arxiv Citation arXiv:2510.05791. Abstract Single fluorescent molecules, behaving as ideal electric dipole emitters, are powerful nanoscopic probes of complex optical fields. Here, this property is exploited to precisely map the polarization and vectorial structure of tightly
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07.10.2025

A versatile microfluidics platform for enhanced multi-target super-resolution microscopy

Authors Basak S, Chi-Vu K, Mougios N, Oleksiievets N, Pollack Y, Brandenburg S, Opazo F, Lehnart SE, Enderlein J, Tsukanov R Journal BioRxiv Citation bioRxiv 2025.10.07.680900. Abstract DNA-based Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is a powerful variant of single-molecule localization microscopy (SMLM) that overcomes the limitations of
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06.10.2025

Transient Non-local Interactions Dominate the Dynamics of Measles Virus NTAIL

Authors Otteson L, Nagy G, Kunkel J, Kodis G, Bock LV, Bignon C, Longhi S, Zheng W, Grubmüller H, Vaiana AC, Vaiana SM Journal Communications Chemistry Citation Commun Chem. 2025 Oct 6;8(1):298. Abstract The RNA genome of measles virus is encapsidated by the nucleoprotein within a helical nucleocapsid that serves
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06.10.2025

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

Authors Ehses K, López-Alonso JP, Antico O, Azem A, Muqit MMK, Ubarretxena-Belandia I, Fernández-Busnadiego R Journal BioRxiv Citation bioRxiv 2025.10.06.680693. Abstract Cells have evolved organelle-specific responses to maintain protein homeostasis (proteostasis). During proteostatic stress, mitochondria downregulate translation and enhance protein folding, yet the underlying mechanisms remain poorly defined. Here, we
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06.10.2025

Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism

Authors Dafsari HS, Deneubourg C, Singh K, Maroofian R, Suprenant Z, Kho AL, Ingham NJ, Steel KP, Sheshadri P, Baur F, Hentrich L, Gerisch B, Zamani M, Alves C, Siddiqui A, Dafsari HS, Salari M, Lang AE, Harris M, Abdelaleem A, Sadeghian S, Azizimalamiri R, Galehdari H, Shariati G, Sedaghat
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01.10.2025

Active intracellular mechanics – a key to cellular function and organization

Authors Eskandari MA, Fischer J, Veyret N, Marx D, Betz T Journal Journal of Cell Science Citation J Cell Sci. 2025 Oct 1;138(19):jcs263874. Abstract Mechanobiology has demonstrated that precise control over mechanical properties at the whole-cell level is crucial for many biological functions. However, comparatively little attention has been paid
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