2024 – Seite 18

01.05.2024

Empirical Optimal Transport between Different Measures Adapts to Lower Complexity

Authors Hundrieser S, Staudt T, Munk A Journal Annales de l’Institut Henri Poincare (B) Probabilites et statistiques Citation Ann. Inst. H. Poincaré Probab. Statist. 60(2): 824-846. Abstract The empirical optimal transport (OT) cost between two probability measures from random data is a fundamental quantity in transport based data analysis. In

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01.05.2024

A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA

Authors Neumann P, Heidemann JL, Wollenhaupt J, Dickmanns A, Agthe M, Weiss MS, Ficner R Journal Acta Crystallographica.Section D, Structural Biology Citation Acta Crystallogr D Struct Biol. 2024 May 1. Abstract CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product

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30.04.2024

An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells

Authors Chen J, Stephan T, Gaedke F, Liu T, Li Y, Schauss A, Chen P, Wulff V, Jakobs S, Jüngst C, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2317703121. Abstract Fluorescence

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26.04.2024

In situ studies of membrane biology by cryo-electron tomography

Authors Keller J, Fernández-Busnadiego R Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2024 Apr 26;88:102363. Abstract Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological samples in near-native environments. Thus, cryo-ET has become the method of choice to analyze the unperturbed organization of cellular membranes.

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24.04.2024

Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy

Authors Wali R, Xu H, Cheruiyot C, Saleem HN, Janshoff A, Habeck M, Ebert A Journal Biological Chemistry Citation Biol Chem. 2024 Apr 24. Abstract Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here,

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23.04.2024

Über Tierversuche sprechen

Mit Transparenz und Fakten einem emotionalen Thema begegnen Tierversuche in der Forschung sind ein Thema, bei dem es oft weniger um Fakten als um emotional aufgeladene Meinungen geht. Dass dies so ist, liegt auch daran, dass sich Wissenschaftlerinnen und Wissenschaftler bei dem Thema oft zurückhaltend oder gar nicht äußern.

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21.04.2024

Myosin II actively regulates Drosophila proprioceptors

Authors Guan C, Nishi K, Kreis CT, Baeumchen O, Goepfert MC, Schmidt CF Journal BioRxiv Citation bioRxiv 2024.04.18.590050. Abstract Auditory receptors can be motile to actively amplify their mechanical input. Here we describe a novel and different type of motility that, residing in supporting cells, shapes physiological responses of mechanoreceptor

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18.04.2024

Microtubules: highway to … arrhythmia?

Authors Liutkute A, Prosser BL, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2024 Apr 18:cvae072. Abstract No abstract available DOI 10.1093/cvr/cvae072 Pubmed Link

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18.04.2024

Cerebellar Ex Vivo Magnetic Resonance Imaging at its Feasibility Limit: Up to 77-Microns Isotropic Resolution using Low-Bandwidth Balanced Steady State Free Precession (LoBa-bSSFP) Sequences and 3T Standard Equipment

Authors Weigel M, Dechent P, Galbusera R, Bahn E, Lu PJ, Kappos L, Brueck W, Stadelmann C, Granziera C Journal BioRxiv Citation bioRxiv 2024.04.18.589707. Abstract Background: Ultra-high-resolution magnetic resonance imaging of the ex vivo brain is increasingly becoming an indispensable tool for studying the morphology and potential pathology of the

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16.04.2024

Gerd Hasenfuß erhielt Leopold-Lichtwitz-Medaille

Professor Dr. med. Gerd Hasenfuß erhielt die Leopold-Lichtwitz-Medaille der Deutschen Gesellschaft für Innere Medizin (DGIM) auf dem Jahreskongress in Anerkennung seiner großen Verdienste um die Innere Medizin. Hasenfuß ist seit 1998 Direktor der Klinik für Kardiologie und Pneumologie, Universitätsprofessor für Innere Medizin an der Universitätsmedizin Göttingen und Mitglied im MBExC.

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