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30.10.2024

Identifiability of the Optimal Transport Cost on Finite Spaces

Authors Gonualez-Sanz A, Groppe M, Munk A Journal Arxiv Citation arXiv:2410.23146. Abstract The goal of optimal transport (OT) is to find optimal assignments or matchings between data sets which minimize the total cost for a given cost function. However, sometimes the cost function is unknown but we have access to
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30.10.2024

Stress Vulnerability Exposed by Mapping Brain Network States to Single-Cell Transcriptomes

Authors Fischer A, Radulovic J Journal Biological Psychiatry Citation Biol Psychiatry. 2024 Dec 1;96(11):832-834. Abstract No abstract available. DOI 10.1016/j.biopsych.2024.08.024   Pubmed Link
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27.10.2024

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal Journal of Chemical Information and Modeling Citation J Chem Inf Model. 2024 Oct 27. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a
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25.10.2024

Increased autonomous bioluminescence emission from mammalian cells by enhanced cofactor synthesis

Authors Brinker T, Gregor C Journal Chemosensors Citation Chemosensors 2024, 12, 223. Abstract The bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness. To improve light emission,
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24.10.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE Journal PLoS One Citation PLoS One. 2024 Oct 24;19(10):e0311203. Abstract Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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Das Bild zeigt eine Eizelle kurz nach dem Eisprung neben dem Follikel. © Christopher Thomas, Tabea Lilian Marx et al. / Max-Planck-Institut für Multidisziplinäre Naturwissenschaften

21.10.2024

Eisprung erstmals von Anfang bis Ende gefilmt

Rund 400 Mal im Leben einer Frau schafft eine reife Eizelle den „Sprung“. Sie wird in den Eileiter entlassen und ist nun bereit, mit einer Spermienzelle zu verschmelzen. Forschenden um Melina Schuh, Christopher Thomas und Tabea Lilian Marx vom Max-Planck-Institut (MPI) für Multidisziplinäre Naturwissenschaften ist es jetzt zum ersten Mal
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Das Bild zeigt eine Eizelle kurz nach dem Eisprung neben dem Follikel. © Christopher Thomas, Tabea Lilian Marx et al. / Max-Planck-Institut für Multidisziplinäre Naturwissenschaften

21.10.2024

Eisprung erstmals von Anfang bis Ende gefilmt

Rund 400 Mal im Leben einer Frau schafft eine reife Eizelle den „Sprung“. Sie wird in den Eileiter entlassen und ist nun bereit, mit einer Spermienzelle zu verschmelzen. Forschenden um Melina Schuh, Christopher Thomas und Tabea Lilian Marx vom Max-Planck-Institut (MPI) für Multidisziplinäre Naturwissenschaften ist es jetzt zum ersten Mal
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21.10.2024

Multiscale scanning with nuisance parameters

Authors König C, Munk A, Werner F Journal Journal of the Royal Statistical Society Series B: Statistical Methodology Citation J R Stat Soc Series B: Statistical Methodology, 2024, 00, 1–19. Abstract We develop a multiscale scanning method to find anomalies in a d-dimensional random field in the presence of nuisance
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21.10.2024

Changes in DNA repair compartments and cohesin loss promote DNA damage accumulation in aged oocytes

Authors Sharma N, Coticchio G, Borini A, Tachibana K, Nasmyth KA, Schuh M Journal Current Biology Citation Curr Biol. 2024 Oct 17:S0960-9822(24)01281-8. Abstract Oocyte loss, a natural process that accelerates as women approach their mid-30s, poses a significant challenge to female reproduction. Recent studies have identified DNA damage as a
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21.10.2024

Visual objects refine head direction coding

Authors Siegenthaler D, Denny H, Skromne Carrasco S, Mayer JL, Peyrache A, Trenholm S, Mace E Journal BioRxiv Citation bioRxiv 2024.10.21.619417. Abstract Animals use visual objects to guide navigation-related behaviors, from hunting prey, to escaping predators, to exploring the world. However, little is known about where visual objects are encoded
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