2023 – Seite 6

19.10.2023

PrP meets alpha-synuclein: Molecular mechanisms and implications for disease

Authors Vieira TCRG, Barros CA, Domingues R, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2023 Oct 19. Abstract The discovery of prions has challenged dogmas and has revolutionized our understanding of protein-misfolding diseases. The concept of self-propagation via protein conformational changes, originally discovered for the prion protein (PrP),

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18.10.2023

Viola Priesemann zum Thema „Emergenz: die verborgene Prinzip des Lebens“

MBExC-Mitglied Viola Priesemann diskutiert in der Wissenschaftsendung scobel (3sat) mit anderen Gästen über das faszinierende Phänomen der Emergenz, als grundlegendem Prinzip des Lebens. Die Emergenzforschung zielt darauf ab, das komplexe Zusammmenspiel unserer Welt besser zu begreifen und mitzugestalten. Link zur Wissenschaftssendung „scobel – Emergenz: das verborgene Prinzip des Lebens“

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17.10.2023

Fluorophore position of headgroup-labeled Gb3 glycosphingolipids in lipid bilayers

Authors Socrier L, Sharma A, Chen T, Flato K, Kettelhoit K, Enderlein J, Werz DB, Steinem C Journal Biophysical Journal Citation Biophys J. 2023 Oct 17;122(20):4104-4112. Abstract Fluorescent lipid probes are an invaluable tool for investigating lipid membranes. In particular, localizing certain receptor lipids such as glycosphingolipids within phase-separated membranes

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16.10.2023

Lyapunov spectra of chaotic recurrent neural networks

Authors Engelken R, Wolf F, Abbott LF Journal Physical Review Research Citation Phys. Rev. Research 5, 043044. Abstract Recurrent networks are widely used as models of biological neural circuits and in artificial intelligence applications. Mean-field theory has been used to uncover key properties of recurrent network models such as the

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13.10.2023

FGFR1 variants contributed to families with tooth agenesis

Authors Yao S, Zhou X, Gu M, Zhang C, Bartsch O, Vona B, Fan L, Ma L, Pan Y Journal Human Genomics Citation Hum Genomics. 2023 Oct 13;17(1):93. Abstract Background: Tooth agenesis is a common dental anomaly that can substantially affect both the ability to chew and the esthetic appearance

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13.10.2023

High-resolution analysis of bound Ca2+ in neurons and synapses

Authors Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2023 Oct 13;7(1):e202302030. Abstract Calcium (Ca2+) is a well-known second messenger in all cells, and is especially relevant for neuronal activity. Neuronal Ca2+ is found in different forms, with a minority

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13.10.2023

Herz und Hirn gemeinsam im Fokus – Öffentliche Ringvorlesung ab 7.11.2023

„Herz und Hirn gemeinsam im Fokus“ lautet der Titel der öffentlichen Ringvorlesung der Universität Göttingen und der Niedersächsischen Akademie der Wissenschaften zu Göttingen im Wintersemester 2023/2024. In der Reihe geben Wissenschaftlerinnen und Wissenschaftler des Göttinger Exzellenzclusters „Multiscale Bioimaging: von molekularen Maschinen zu Netzwerken erregbarer Zellen“ (MBExC) am Beispiel ihrer Forschungsergebnisse

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11.10.2023

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly

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07.10.2023

The ultrametric Gromov-Wasserstein distance

Authors Mémoli F, Munk A, Wan Z, Weitkamp C Journal Discrete & Computational Geometry Citation Discrete Comput Geom (2023) Abstract We investigate compact ultrametric measure spaces which form a subset Uw of the collection of all metric measure spaces Mw. In analogy with the notion of the ultrametric Gromov–Hausdorff distance

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06.10.2023

Diversity matters – extending sound intensity coding by inner hair cells via heterogeneous synapses

Authors Moser T, Karagulyan N, Neef J, Jaime Tobon LM Journal EMBO Journal Citation EMBO J. 2023.e114587. Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal

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