2023

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06.11.2023

Structure of the transcribing RNA polymerase II-Elongin complex

Authors Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2023 Nov 6. Abstract Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM
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06.11.2023

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome

Authors Kutschka I, Bertero E, Wasmus C, Xiao K, Yang L, Chen X, Oshima Y, Fischer M, Erk M, Arslan B, Alhasan L, Grosser D, Ermer KJ, Nickel A, Kohlhaas M, Eberl H, Rebs S, Streckfuss-Bömeke K, Schmitz W, Rehling P, Thum T, Higuchi T, Rabinowitz J, Maack C, Dudek
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02.11.2023

Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

Authors Shi R, Reichardt M, Fiegle DJ, Küpfer LK, Czajka T, Sun Z, Salditt T, Dendorfer A, Seidel T, Bruegmann T Journal Cardiovascular Research Citation Cardiovasc Res. 2023 Nov 2:cvad141. Abstract Aims: Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches
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Prof. Dr. Ricarda Richter-Dennerlein (Photo: SPförtner/MBExC)

01.11.2023

Ricarda Richter-Dennerlein erhält erste „Niedersachsen-Impuls-Professur“

Ricarda Richter-Dennerlein, Leiterin der Arbeitsgruppe „Biochemie makromolekularer Komplexe“ am Institut für Molekularbiologie der Universitätsmedizin Göttingen (UMG) und Mitglied im Exzellenzcluster MBExC, hat die erste vom Niedersächsischen Ministerium für Wissenschaft und Kultur und von der VolkswagenStiftung finanzierte „Niedersachsen-Impuls-Professur“ erhalten. Die neue Förderlinie unterstützt Hochschulen bei Berufungs- und Bleibeverhandlungen mit exzellenten Wissenschaftler*innen
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30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,
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30.10.2023

An NFATc1/SMAD3/cJUN complex restricted to SMAD4-deficient pancreatic cancer guides rational therapies

Authors Hasselluhn MC, Schlösser D, Versemann L, Schmidt GE, Ulisse M, Oschwald J, Zhang Z, Hamdan F, Xiao H, Kopp W, Spitalieri J, Kellner C, Schneider C, Reutlinger K, Nagarajan S, Steuber B, Sastra SA, Palermo CF, Appelhans J, Bohnenberger H, Todorovic J, Kostyuchek I, Ströbel P, Bockelmann A, König
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26.10.2023

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

Authors Binotti B, Ninov M, Cepeda AP, Ganzella M, Matti U, Riedel D, Urlaub H, Sambandan S, Jahn R Journal Autophagy Citation Autophagy. 2023 Oct 26:1-19. Abstract In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane
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24.10.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J. Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2305460120. Abstract Pre- and postsynaptic forms of long-term potentiation
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23.10.2023

Synapsin condensation controls synaptic vesicle sequestering and dynamics

Authors Hoffmann C, Rentsch J, Tsunoyama TA, Chhabra A, Aguilar Perez G, Chowdhury R, Trnka F, Korobeinikov AA, Shaib AH, Ganzella M, Giannone G, Rizzoli SO, Kusumi A, Ewers H, Milovanovic D Journal Nature Communications Citation Nat Commun. 2023 Oct 23;14(1):6730. Abstract Neuronal transmission relies on the regulated secretion of
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21.10.2023

The unique biomechanics of intermediate filaments – From single filaments to cells and tissues

Authors Rölleke U, Kumari P, Meyer R, Köster S Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2023 Oct 21;85:102263. Abstract Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the eukaryotic cytoskeleton and each of the three filament types contributes very distinct mechanical properties to
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