Oktober

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13.10.2023

High-resolution analysis of bound Ca2+ in neurons and synapses

Authors Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2023 Oct 13;7(1):e202302030. Abstract Calcium (Ca2+) is a well-known second messenger in all cells, and is especially relevant for neuronal activity. Neuronal Ca2+ is found in different forms, with a minority
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MBExC: Herz und Hirn gemeinsam im Fokus. Grafik: A.Chizhik/MBExC

13.10.2023

Herz und Hirn gemeinsam im Fokus – Öffentliche Ringvorlesung ab 7.11.2023

„Herz und Hirn gemeinsam im Fokus“ lautet der Titel der öffentlichen Ringvorlesung der Universität Göttingen und der Niedersächsischen Akademie der Wissenschaften zu Göttingen im Wintersemester 2023/2024. In der Reihe geben Wissenschaftlerinnen und Wissenschaftler des Göttinger Exzellenzclusters „Multiscale Bioimaging: von molekularen Maschinen zu Netzwerken erregbarer Zellen“ (MBExC) am Beispiel ihrer Forschungsergebnisse
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11.10.2023

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly
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07.10.2023

The ultrametric Gromov-Wasserstein distance

Authors Mémoli F, Munk A, Wan Z, Weitkamp C Journal Discrete & Computational Geometry Citation Discrete Comput Geom (2023) Abstract We investigate compact ultrametric measure spaces which form a subset Uw of the collection of all metric measure spaces Mw. In analogy with the notion of the ultrametric Gromov–Hausdorff distance
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06.10.2023

Diversity matters – extending sound intensity coding by inner hair cells via heterogeneous synapses

Authors Moser T, Karagulyan N, Neef J, Jaime Tobon LM Journal EMBO Journal Citation EMBO J. 2023.e114587. Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal
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06.10.2023

Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

Authors Tolstik E, Lehnart SE, Soeller C, Lorenz K, Sacconi L Journal Trends in Biotechnology Citation Trends Biotechnol. 2023 Oct 6:S0167-7799(23)00241-X. Abstract Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive understanding of the heart and its functions at various levels, from the molecular to the
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05.10.2023

Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry

Authors Roeder SS, Bonnin EA, Wu TD, Guerquin-Kern JL, Jabari S, Brandner S, Eyüpoglu IY, Gollwitzer S, Hamer HM, Gerner ST, Döppner TR, Rummel C, Englund E, Heimke-Brinck R, Borst T, Daniel C, Amann K, Schlötzer-Schrehardt U, Tonchev AB, Roessler K, Schwab S, Bergmann O, Rizzoli SO, Huttner HB Journal
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02.10.2023

X-ray phase contrast 3D virtual histology characterises complex tissue architecture in colorectal cancer

Authors Svetlove A, Griebel T, Albers J, D’Amico L, Nolte P, Tromba G, Bohnenberger H, Alves F, Dullin C Journal Frontiers in Gastroenterology Citation Front. Gastroenterol.Sec. Gastroenterology and Cancer. Volume 2 – 2023 Abstract Precise morphological analysis of tumour tissue samples is crucial for accurate diagnosis and staging of colorectal
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