Oktober 2023 – MBExC

30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,

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30.10.2023

An NFATc1/SMAD3/cJUN complex restricted to SMAD4-deficient pancreatic cancer guides rational therapies

Authors Hasselluhn MC, Schlösser D, Versemann L, Schmidt GE, Ulisse M, Oschwald J, Zhang Z, Hamdan F, Xiao H, Kopp W, Spitalieri J, Kellner C, Schneider C, Reutlinger K, Nagarajan S, Steuber B, Sastra SA, Palermo CF, Appelhans J, Bohnenberger H, Todorovic J, Kostyuchek I, Ströbel P, Bockelmann A, König

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26.10.2023

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

Authors Binotti B, Ninov M, Cepeda AP, Ganzella M, Matti U, Riedel D, Urlaub H, Sambandan S, Jahn R Journal Autophagy Citation Autophagy. 2023 Oct 26:1-19. Abstract In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane

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24.10.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J. Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2305460120. Abstract Pre- and postsynaptic forms of long-term potentiation

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23.10.2023

Synapsin condensation controls synaptic vesicle sequestering and dynamics

Authors Hoffmann C, Rentsch J, Tsunoyama TA, Chhabra A, Aguilar Perez G, Chowdhury R, Trnka F, Korobeinikov AA, Shaib AH, Ganzella M, Giannone G, Rizzoli SO, Kusumi A, Ewers H, Milovanovic D Journal Nature Communications Citation Nat Commun. 2023 Oct 23;14(1):6730. Abstract Neuronal transmission relies on the regulated secretion of

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21.10.2023

The unique biomechanics of intermediate filaments – From single filaments to cells and tissues

Authors Rölleke U, Kumari P, Meyer R, Köster S Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2023 Oct 21;85:102263. Abstract Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the eukaryotic cytoskeleton and each of the three filament types contributes very distinct mechanical properties to

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19.10.2023

PrP meets alpha-synuclein: Molecular mechanisms and implications for disease

Authors Vieira TCRG, Barros CA, Domingues R, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2023 Oct 19. Abstract The discovery of prions has challenged dogmas and has revolutionized our understanding of protein-misfolding diseases. The concept of self-propagation via protein conformational changes, originally discovered for the prion protein (PrP),

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18.10.2023

Viola Priesemann zum Thema „Emergenz: die verborgene Prinzip des Lebens“

MBExC-Mitglied Viola Priesemann diskutiert in der Wissenschaftsendung scobel (3sat) mit anderen Gästen über das faszinierende Phänomen der Emergenz, als grundlegendem Prinzip des Lebens. Die Emergenzforschung zielt darauf ab, das komplexe Zusammmenspiel unserer Welt besser zu begreifen und mitzugestalten. Link zur Wissenschaftssendung „scobel – Emergenz: das verborgene Prinzip des Lebens“

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17.10.2023

Fluorophore position of headgroup-labeled Gb3 glycosphingolipids in lipid bilayers

Authors Socrier L, Sharma A, Chen T, Flato K, Kettelhoit K, Enderlein J, Werz DB, Steinem C Journal Biophysical Journal Citation Biophys J. 2023 Oct 17;122(20):4104-4112. Abstract Fluorescent lipid probes are an invaluable tool for investigating lipid membranes. In particular, localizing certain receptor lipids such as glycosphingolipids within phase-separated membranes

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16.10.2023

Lyapunov spectra of chaotic recurrent neural networks

Authors Engelken R, Wolf F, Abbott LF Journal Physical Review Research Citation Phys. Rev. Research 5, 043044. Abstract Recurrent networks are widely used as models of biological neural circuits and in artificial intelligence applications. Mean-field theory has been used to uncover key properties of recurrent network models such as the

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