April

Authors Khan A, Markus AM, Svetlove A, Hülsmann S, Alves F, Dullin C Journal Research Square Citation Research Square, 12 April 2023, preprint. Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive, incurable, and debilitating fibrotic disease. Nintedanib – an oral tyrosine kinase inhibitor – significantly slows the IPF

Authors Volpe G, Maragò OM, Rubinzstein-Dunlop H, Pesce G, Stilgoe AB, Volpe G, Tkachenko G, Truong VG, Chormaic SN, Kalantarifard F, Elahi P, Käll M, Callegari A, Marqués MI, Neves AAR, Moreira WL, Fontes A, Cesar CL, Saija R, Saidi A, Beck P, Eismann JS, Banzer P, Fernandes TFD, Pedaci

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J   Journal BioRxiv   Citation bioRxiv 2023.04.11.535831.   Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer

Authors Lenner N, Häring M, Eule S, Großhans J, Wolf F   Journal ArXiv   Citation arXiv:2304.04279.   Abstract The dynamics of living systems often serves the purpose of reaching functionally important target states. We previously proposed a theory to analyze stochastic biological dynamics evolving towards target states in reverse

Authors Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, Leonov A, Carlos Fuentes-Monteverde J, Wegstroth M, Giller K, Mathies G, Giese A, Becker S, Griesinger C, Andreas LB Journal Methods Citation Methods. 2023 Apr 8:S1046-2023(23)00056-7. Abstract Small molecules that bind to oligomeric protein species such as

Authors Lenner N, Eule S, Großhans J, Wolf F Journal Arxiv Citation arXiv:2304.03226. Abstract Mesoscopic bio-systems typically evolve towards functionally important target states, such as cell-cycle checkpoints or decision boundaries for the release of specific behaviors. For the data-driven inference of the underlying directional out-of-equilibrium dynamics, we here develop a

Authors Chatterjee M, Özdemir S, Kunadt M, Koel-Simmelink M, Boiten W, Piepkorn L, Pham TV, Chiasserini D, Piersma SR, Knol JC, Möbius W, Mollenhauer B, van der Flier WM, Jimenez CR, Teunissen CE, Jahn O, Schneider A Journal Alzheimer’s & Dementia: The Journal of the Alzheimers Association Citation Alzheimers Dement.

Authors Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, Liutkute A, Ritter M, Jung P, Stelzer L, Hüsgen LM, Klopp M, Rubio T, Fakuade FE, Mason FE, Hartmann N, Pabel S, Streckfuss-Bömeke K, Cyganek L, Sossalla S, Heijman J, Voigt N Journal Basic Research in Cardiology

Authors Schilbach S, Wang H, Dienemann C, Cramer P Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2220542120. Abstract For transcription initiation, RNA polymerase II (Pol II) forms a preinitiation complex (PIC) that associates with the general coactivator Mediator. Whereas