2022

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10.01.2022

The Role of Junctophilin Proteins in Cellular Function

Authors Lehnart SE, Wehrens XHT Journal Physiological Reviews Citation Physiol Rev. 2022 Jan 10. Abstract Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum. Tethering of these membrane structures results in the formation of highly organized subcellular junctions
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10.01.2022

Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells

Authors Pavez-Giani MG, Cyganek L Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Jan 10;9:800529. Abstract   Around one third of patients with mitochondrial disorders develop a kind of cardiomyopathy. In these cases, severity is quite variable ranging from asymptomatic status to severe manifestations including
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06.01.2022

Prion-like α-synuclein pathology in the brain of infants with Krabbe disease

Authors Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D Journal Brain Citation Brain. 2022 May 24;145(4):1257-1263. Abstract Krabbe disease is an infantile
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04.01.2022

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Authors Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2022 Jan 4. Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy
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04.01.2022

Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin‑1 -PI(4,5)P2 Interaction in Constrained Geometries

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force
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04.01.2022

Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron‐enriched genes

Authors Michurina A, Sakib S, Kerimoglu C, Krüger DM, Kaurani L, Islam R, Joshi PD, Schröder S, Centeno TP, Zhou J, Pradhan R, Cha J, Xu X, Eichele G, Zeisberg EM, Kranz A, Stewart FA, Fischer A Journal EMBO Journal Citation EMBO J. 2022 Jan 4; 41(1): e106459. Abstract In
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Foto: © Johannes Pauly / Max-Planck-Institut für Multidisziplinäre Naturwissenschaften

03.01.2022

Neues Max-Planck-Institut in Göttingen verbindet Natur- und Medizinwissenschaften

Die Göttinger Max-Planck-Institute (MPI) für biophysikalische Chemie und für Experimentelle Medizin haben zum 1. Januar 2022 fusioniert. So entsteht ein neues MPI, das Max-Planck-Institut für Multidisziplinäre Naturwissenschaften. Es wird ein deutlich breiteres Forschungsspektrum abdecken und so die disziplinäre Vielfalt und Zusammenarbeit fördern. Mit insgesamt 16 Abteilungen und über 25 Forschungsgruppen
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