2022

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25.04.2022

Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

Authors Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. Abstract Alpha-synuclein (aSyn) is a central
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21.04.2022

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Authors Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W Journal Nature Communications Citation Nat Commun. 2022 Mar 4;13(1):1163.  Abstract Myelin, the electrically insulating sheath on axons, undergoes dynamic
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21.04.2022

Background calcium influx in arrhythmia: lead actor or extra?

Authors Fakuade FE, Fauconnier J, Voigt N. Journal Journal of Physiology Citation J Physiol. 2022 Apr 21. Abstract No abstract available DOI 10.1113/JP283032 Pubmed Link  
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19.04.2022

Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Authors Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D Journal EMBO Reports Citation EMBO Rep. 2022 Apr 19:e53890. Abstract Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of
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15.04.2022

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration

Authors Luebben AV, Bender D, Becker S, Crowther LM, Erven I, Hofmann K, Söding J, Klemp H, Bellotti C, Stäuble A, Qiu T, Kathayat RS, Dickinson BC, Gärtner J, Sheldrick GM, Krätzner R, Steinfeld R Journal Science Advances Citation Sci Adv. 2022 Apr 15;8(15):eabj8633. Abstract Genetic CLN5 variants are associated
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Indicated are the intracellular steps of the Gq signaling cascade, which can now be controlled by scientists using light to drive activity in transgenic mouse hearts (left) and contractions in the small intestine (right). Source: Prof. Brügmann / umg.

14.04.2022

Neues Werkzeug für die Optogenetik: menschlicher Rezeptor zur Untersuchung der Zellfunktion mit Licht

Wissenschaftler*innen der Universitätsmedizin Göttingen identifizieren den menschlichen OPN5 Rezeptor als neues Target zur Steuerung der Zellaktivität und Untersuchung der Zellkommunikation mit Licht. Veröffentlicht am 1. April 2022 in renommierter Fachzeitschrift Nature Communications. Link zur MBExC Pressemitteilung
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Indicated are the intracellular steps of the Gq signaling cascade, which can now be controlled by scientists using light to drive activity in transgenic mouse hearts (left) and contractions in the small intestine (right). Source: Prof. Brügmann / umg.

14.04.2022

Neues Werkzeug für die Optogenetik: menschlicher Rezeptor zur Untersuchung der Zellfunktion mit Licht

Wissenschaftler*innen der Universitätsmedizin Göttingen identifizieren den menschlichen OPN5 Rezeptor als neues Target zur Steuerung der Zellaktivität und Untersuchung der Zellkommunikation mit Licht. Veröffentlicht am 1. April 2022 in renommierter Fachzeitschrift Nature Communications. Die Gq Proteine und die von ihnen ausgelöste Signalkaskade spielen in allen Zellen unseres Körpers eine wichtige Rolle:
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13.04.2022

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Authors Vincenti I, Page N, Steinbach K, Yermanos A, Lemeille S, Nunez N, Kreutzfeldt M, Klimek B, Di Liberto G, Egervari K, Piccinno M, Shammas G, Mariotte A, Fonta N, Liaudet N, Shlesinger D, Liuzzi AR, Wagner I, Saadi C, Stadelmann C, Reddy S, Becher B, Merkler D Journal Science
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11.04.2022

Retinal receptive-field substructure: scaffolding for coding and computation

Authors Zapp SJ, Nitsche S, Gollisch T Journal Trends in Neurosciences Citation Trends Neurosci. 2022 Apr 11:S0166-2236(22)00056-X. Abstract The center-surround receptive field of retinal ganglion cells represents a fundamental concept for how the retina processes and encodes visual information. Yet, traditional approaches of using the receptive field as a linear
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07.04.2022

Rapidly Signal-enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance

Authors Ding Y,Korchak S, Mamone S, Jagtap AP, Stevanato G, Sternkopf S, Moll D, Schroeder H, Becker S, Fischer A, Gerhardt E, Outeiro TF, Opazo F, Griesinger C, Glöggler S Journal Chemistry Methods Citation Chem. Methods 2022, e202200023. Abstract Nuclear magnetic resonance (NMR) is widely applied from analytics to biomedicine
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