2021

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25.01.2021

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

Authors Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE Journal Circulation Research Citation
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21.01.2021

Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial.

Authors Backhaus SJ, Lange T, George EF, Hellenkamp K, Gertz RJ, Billing M, Wachter R, Steinmetz M, Kutty S, Raaz U, Lotz J, Friede T, Uecker M, Hasenfuß G, Seidler T, Schuster A Journal Circulation Citation Circulation. 2021 Jan 21. Abstract Background: Right heart catheterisation (RHC) using exercise-stress is the
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20.01.2021

Epigenetic gene expression links heart failure to memory impairment

Authors Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 Jan 20:e11900. Abstract In current clinical practice, care
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19.01.2021

Regulation of a subset of release-ready vesicles by the presynaptic protein Mover

Authors Pofantis E, Neher E, Dresbach T Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022551118. Abstract Neurotransmitter release occurs by regulated exocytosis from synaptic vesicles (SVs). Evolutionarily conserved proteins mediate the essential aspects of this process, including the membrane
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18.01.2021

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

Authors Hofemeier AD, Limón T, Muenker TM, Wallmeyer B, Jurado A, Afshar ME, Ebrahimi M, Tsukanov R, Oleksiievets N, Enderlein J, Gilbert PM, Betz T Journal Elife Citation Elife. 2021 Jan 18;10:e60145. Abstract Tension and mechanical properties of muscle tissue are tightly related to proper skeletal muscle function, which makes
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The Covid-19 drug remdesivir (purple) is incorporated into the new RNA chain during the copying process and suppresses the duplication of the coronavirus genome. © Hauke Hillen, Goran Kokic, and Patrick Cramer / Max Planck Institute for Biophysical Chemistry

18.01.2021

Warum Remdesivir das Coronavirus nicht vollständig ausschaltet

Remdesivir ist das erste Medikament gegen Covid-19, das in Europa und den Vereinigten Staaten unter Vorbehalt zugelassen wurde. Das Medikament soll die schnelle Vermehrung des SARS-CoV-2-Virus in menschlichen Zellen unterdrücken, indem es die virale Kopiermaschine, die sogenannte RNA-Polymerase, blockiert. Forscher des Max-Planck-Instituts (MPI) für biophysikalische Chemie in Göttingen (darunter MBExC-Mitglied
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17.01.2021

Transcriptionally active enhancers in human cancer cells

Authors Lidschreiber K, Jung LA, von der Emde H, Dave K, Taipale J, Cramer P, Lidschreiber M Journal Molecular Systems Biology Citation Mol Syst Biol. 2021 Jan;17(1):e9873. Abstract The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Here, we use transient transcriptome sequencing (TT-seq)
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15.01.2021

Aneuploidy in human eggs: contributions of the meiotic spindle

Authors Thomas C, Cavazza T, Schuh M Journal Biochemical Society Transactions Citation Biochem Soc Trans. 2021 Jan 15:BST20200043. Abstract Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from
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15.01.2021

Structure of a transcribing RNA polymerase II–U1 snRNP complex

Authors Zhang S, Aibara S, Vos SM, Agafonov DE, Lührmann R, Cramer P Journal Science Citation Science. 2021 Jan 15;371(6526):305-309. Abstract To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron
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14.01.2021

Phase Separation during Germline Development

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work
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