2020

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10.08.2020

The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

Authors Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2020, 21(16), 5724. Abstract Neurodevelopmental and late-onset neurodegenerative disorders present as separateentities that are clinically and neuropathologically quite distinct. However, recent evidence hashighlighted surprising commonalities
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10.08.2020

Reliable estimation of membrane curvature for cryo-electron tomography

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a
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06.08.2020

RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies

Authors Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF Journal Brain Pathology Citation Brain Pathol. 2020;10.1111/bpa.12890. Abstract Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X‐linked Parkinson’s disease (PD). Physiologically, RAB39B is localized
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CRISPR/Cas9-repaired iPSC-cardiomyocytes display a restored function and a normalized muscle contraction. © Cyganek, UMG

05.08.2020

CRISPR/Cas9 – GENE EDITING: Neuer Therapieansatz für angeborene Herzfehler

Wissenschaftler am Herzzentrum der Universitätsmedizin Göttingen haben erstmals einen Ansatz für eine personalisierte Therapieoption mit „Gene Editing“ für das Noonan-Syndrom gefunden. Veröffentlicht in der renommierten Fachzeitschrift „Circulation„. Link zur Pressemitteilung des DZHK
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CRISPR/Cas9-repaired iPSC-cardiomyocytes display a restored function and a normalized muscle contraction. © Cyganek, UMG

05.08.2020

CRISPR/Cas9 – GENE EDITING: New therapeutic approach for congenital heart defects

Scientists at the Heart Center of the University Medical Center Göttingen have for the first time found an approach for a personalised therapy option with „gene editing“ for the Noonan Syndrome. Publication in the renowned journal „Circulation„. (umg/ mbexc) Congenital heart diseases are the most common organ defects. They occur
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01.08.2020

Remyelination in multiple sclerosis: from basic science to clinical translation

Authors Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B Journal The Lancet. Neurology Citation The Lancet. Neurology. 2020 Aug;19(8):678-688. Abstract The treatment of multiple sclerosis has been transformed by the successful development of immunotherapies that efficiently reduce disease activity and related clinical relapses during the relapsing-remitting phase of
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30.07.2020

Dopamine promotes the neurodegenerative potential of β-synuclein

Authors Raina A, Leite K, Guerin S, Mahajani SU, Chakrabarti KS, Voll D, Becker S, Griesinger C, Bähr M, Kügler S Journal Journal of Neurochemistry Citation J Neurochem. 2020 Jul 30. Abstract A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is
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30.07.2020

Effects of pharmacological modulators of α‐synuclein and tau aggregation and internalization

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect
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Snapshot of protein mobility in the synapse. A region within the synapse at the edge of the synaptic vesicle cluster is shown. Organelles in grey represent synaptic vesicles (each ~40 nm in diameter). Various shapes correspond to different protein molecules, with each protein species having its own shape, as extracted from stuctural studies. The proteins are colored based on the speed of movement of every individual molecule in every position, from dark violet (the slowest one) to yellow (the fastest). Most proteins move slowly next to the synaptic vesicles, and are much faster in the vesicle-free region. Source: Reshetniak and co-authors

30.07.2020

Auf einen Streich: Wie sich Proteine in lebenden Synapsen bewegen

Einem Team von Wissenschaftlern um Prof. Dr. Silvio O. Rizzoli und Prof. Dr. Sarah Köster ist es erstmals gelungen, die simultane Bewegung von 45 Proteinen in einer Zelle zu visualisieren und damit die Mobilität von Tausenden von Proteinmolekülen in realistischer Form und Größe innerhalb einer Synapse zu demonstrieren. Die Studie
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Snapshot of protein mobility in the synapse. A region within the synapse at the edge of the synaptic vesicle cluster is shown. Organelles in grey represent synaptic vesicles (each ~40 nm in diameter). Various shapes correspond to different protein molecules, with each protein species having its own shape, as extracted from stuctural studies. The proteins are colored based on the speed of movement of every individual molecule in every position, from dark violet (the slowest one) to yellow (the fastest). Most proteins move slowly next to the synaptic vesicles, and are much faster in the vesicle-free region. Source: Reshetniak and co-authors

30.07.2020

In one sweep: Visualization of protein mobility in the synapse

(mbexc/umg) All functions of the neural system, including body movements, sensory reactions, and information processing in the brain, depend on the constant and controlled communication between nerve cells. The contact sites between nerve cells, the synapses, have been extensively studied over the last decades, extending our understanding of brain functioning
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