2020

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01.11.2020

Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control

Authors Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H Journal Genetics Citation Genetics. 2020 Nov;216(3):735-752. Abstract Sleep is a conserved behavioral state. Invertebrates typically show quiet sleep, whereas in mammals, sleep consists of periods of nonrapid-eye-movement sleep (NREMS) and REM
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30.10.2020

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity.

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore
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30.10.2020

Defining the architecture of the human TIM22 complex by chemical crosslinking

Authors Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, Deckers M, Rehling P Journal FEBS Letters Citation FEBS Lett. 2020 Oct 30. Abstract The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The Translocase of the Inner
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28.10.2020

Connexin hemichannels in atrial fibrillation – Orphaned and irrelevant?

Authors Fakuade FE, Tomsits P, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2020 Oct 28:cvaa308. Abstract No abstract available DOI 10.1093/cvr/cvaa308 Pubmed Link  
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26.10.2020

Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation

Authors Sarkar A, Wang I, Enderlein J, Derouard J, Delon A Journal Optics Express Citation Opt Express. 2020 Oct 26;28(22):32936-32954. Abstract Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to image objects hidden behind visually opaque layers. Here, we show that a correlation analysis
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The cartoon illustration shows a part of the apoferritin protein (yellow) with a tyrosine side chain highlighted in grey. The amino acid tyrosine consists of several atoms that are individually recognizable in the structure (red grid structures). © Holger Stark / MPI-BPC

21.10.2020

Weltrekordauflösung in der Kryo-Elektronenmikroskopie

Prof. Dr. Holger Stark und sein Team am Max-Planck-Institut (MPI) für biophysikalische Chemie haben eine entscheidende Auflösungsgrenze in der Kryo-Elektronenmikroskopie durchbrochen: Den Wissenschaftlern gelang es, einzelne Atome in einer Proteinstruktur zu beobachten und die schärfsten Bilder zu machen, die jemals mit dieser Methode aufgenommen wurden. Solche noch nie dagewesenen Details
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Cells cultured in the laboratory (cyan). Artificial viruses that mimic SARS-CoV-2 (magenta) infect the cells via ACE2 and neuropilin-1. Source: DZNE/ Liliana Pedro-Domingues

20.10.2020

Coronavirus: Studie findet weiteren Türöffner zur Zelle

Das Coronavirus SARS-CoV-2 ist dafür bekannt, Zellen über den Rezeptor ACE2 zu infizieren. Ein internationales Forschungsteam unter deutsch-finnischer Federführung hat jetzt Neuropilin-1 als Faktor identifiziert, der den Eintritt von SARS-CoV-2 über den bekannten Rezeptor ACE 2 in das Innere der Zellen offenbar erleichtert. Neuropilin-1 ist in den Schleimhäuten der Atemwege
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20.10.2020

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Authors Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu
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19.10.2020

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

Authors Wildemann B, Jarius S, Franz J, Ruprecht K, Reindl M, Stadelmann C Journal Acta Neuropathologica Citation Acta Neuropathol. 2020 Oct 19. Abstract no abstract available DOI 10.1007/s00401-020-02236-5 Pubmed Link  
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14.10.2020

Heterogeneous Idealization of Ion Channel Recordings — Open Channel Noise

Authors Pein F, Bartsch A, Steinem C, Munk A Journal IEEE Transactions on Nanobioscience Citation IEEE Trans Nanobioscience. 2020 Oct 14;PP. Abstract We propose a new model-free segmentation method for idealizing ion channel recordings. This method is designed to deal with heterogeneity of measurement errors. This in particular applies to
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