2020

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29.07.2020

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as
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Optical cochlear implant in the cochlea of a rat. Source: Dr. Daniel Keppeler, Institute for Auditory Neurosciences, UMG.

22.07.2020

Auf dem Weg zum optischen Cochlea-Implantat

Ein interdisziplinäres Team von Wissenschaftler*innen der Universitätsmedizin Göttingen und der Albert-Ludwigs-Universität Freiburg konnte mittels Leuchtdioden-basierter optischer Cochlea-Implantate erstmals lichtgesteuertes Verhalten in tauben Nagetieren erzeugen. Nach 12 Jahren Forschung zu grundlegenden Fragen zum Hören mit Licht ist die Hörforschung am Göttingen Campus um Prof. Dr. Tobias Moser, Direktor des Instituts für
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Optical cochlear implant in the cochlea of a rat. Source: Dr. Daniel Keppeler, Institute for Auditory Neurosciences, UMG.

22.07.2020

On the way to the optical cochlear implant

Interdisciplinary team of scientists from the University Medical Center Göttingen and the University of Freiburg generate for the first time light-controlled behaviour in deaf rodents using optical cochlear implants based on light-emitting diodes. Published in Science Translational Medicine. (mbexc/umg) The cochlear implant (CI) enables worldwide over 700,000 people with profoundly
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22.07.2020

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

Authors Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T Journal Science Translational Medicine Citation Sci. Transl. Med. 12, eabb8086 (2020). Abstract Cochlear implants provide the brain
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21.07.2020

Three-dimensional beating dynamics of Chlamy- domonas flagella

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal bioRxiv Citation bioRxiv 2020.07.20.212159. Abstract Axonemes are the basic structure of motile cilia and flagella, and the investigation of how they function and move requires rapid three-dimensional imaging. We built a multi-plane
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20.07.2020

Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels

Authors Bonnin EA, Rizzoli SO Journal Frontiers in Behavioral Neuroscience Citation Front Behav Neurosci. 2020 Jul 20;14:124. Abstract The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically
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The lab of Dr. Opazo develops new probes from alpaca antibodies (nanobodies) to be used as tools in neurosciences and super-resolution microscopy. The Alpacas Pepe, Atahualpa, James and Castano (l-r), NanoTag Biotechnology GmbH. Photo: Dr. F. Opazo, BIN.

17.07.2020

Neuer Biosensor spürt die Übertragung des Parkinson-assoziierten α-Synuklein Proteins von einer Zelle zur anderen auf

Wissenschaftler des Exzellenzclusters Multiscale Bioimaging entwickeln einen neuen Biosensor, der die Übertragung von menschlichem α-Synuclein, einem Schlüsselprotein der Parkinson-Krankheit, nachweisen kann. Veröffentlicht in Nature Communications. In der kürzlich veröffentlichten Studie beschreiben die Wissenschaftler*innen unter Leitung von Dr. Felipe Opazo (BIN) und Prof. Dr. Silvio O. Rizzoli, Direktor des Instituts für
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The lab of Dr. Opazo develops new probes from alpaca antibodies (nanobodies) to be used as tools in neurosciences and super-resolution microscopy. The Alpacas Pepe, Atahualpa, James and Castano (l-r), NanoTag Biotechnology GmbH. Photo: Dr. F. Opazo, BIN.

17.07.2020

New biosensor detects cell-to-cell transmission of the Parkinson-associated protein α-Synuclein

Scientists of the Cluster of Excellence Multiscale Bioimaging develop a new biosensor capable of detecting the transmission of human α-synuclein, a key protein associated to Parkinson’s disease. Published in Nature Communications. (umg/mbexc) Human alpha-synuclein (hαSyn) is a physiological protein that is primarily found in nerve cells, and is involved in
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Optical cochlear implant in the cochlea of a gerbil

Optical cochlear implant in the cochlea of a gerbil: The Reconstruction of the spiral-shaped cochlea of a gerbil (grey) was generated by X-ray tomography images at the Institute for X-ray Physics (Prof. Dr. Tim Salditt) at the University of Göttingen. The spiral ganglion with the auditory nerve cells is shown in purple. The optical cochlear implant is shown in blue, the μLEDs are visible as blue dots. Source: Prof. Salditt, University of Göttingen

06.07.2020

Lighting array in the ear: First use of multi-channel cochlear implants with microscale light-emitting diodes

A milestone in hearing research: Researchers at the University Medical Center Göttingen and the University of Freiburg combine for the first time gene therapy in the cochlea with optical cochlear implants to optogenetically activate the auditory pathway in gerbils. Published in EMBO Molecular Medicine. (umg/mbexc) Conventional hearing prostheses, so-called cochlear
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06.07.2020

A comparative analysis of the mobility of 45 proteins in the synaptic bouton

Authors Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli S Journal EMBO Journal Citation EMBO J. 2020 Jul 6;e104596. Abstract Many proteins involved in synaptic transmission are well known, and their features, as their abundance or spatial distribution, have been analyzed
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