Urlaub, Henning

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16.07.2024

Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy

Authors Paulke NJ, Fleischhacker C, Wegener JB, Riedemann GC, Cretu C, Mushtaq M, Zaremba N, Möbius W, Zühlke Y, Wedemeyer J, Liebmann L, Gorshkova AA, Kownatzki-Danger D, Wagner E, Kohl T, Wichmann C, Jahn O, Urlaub H, Toischer K, Hasenfuß G, Moser T, Preobraschenski J, Lenz C, Rog-Zielinska EA, Lehnart
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11.07.2024

A roadmap for ribosome assembly in human mitochondria

Authors Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2024 Jul 11. Abstract Mitochondria contain dedicated ribosomes
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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27.05.2024

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the
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03.04.2024

Structural basis of Integrator-dependent RNA polymerase II termination

Authors Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P   Journal Nature   Citation Nature. 2024 Apr 3.   Abstract The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator
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11.03.2024

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3′-UTR and promoting Rag1 mRNA expression

Authors Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer
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16.02.2024

RNA helicase IGHMBP2 regulates THO complex to ensure cellular mRNA homeostasis

Authors Prusty AB, Hirmer A, Sierra-Delgado JA, Huber H, Guenther UP, Schlosser A, Dybkov O, Yildirim E, Urlaub H, Meyer KC, Jablonka S, Erhard F, Fischer U   Journal Cell Reports   Citation Cell Rep. 2024 Feb 16;43(2):113802.   Abstract RNA helicases constitute a large protein family implicated in cellular
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08.02.2024

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1

Authors Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S   Journal Nature Structural & Molecular Biology   Citation Nat Struct Mol Biol (2024).   Abstract Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system
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27.12.2023

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses

Authors Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos
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