Rizzoli, Silvio

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05.10.2024

The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function

Authors Reshetniak S, Bogaciu CA, Bonn S, Brose N, Cooper BH, D’Este E, Fauth M, Fernández-Busnadiego R, Fiosins M, Fischer A, Georgiev SV, Jakobs S, Klumpp S, Köster S, Lange F, Lipstein N, Macarrón-Palacios V, Milovanovic D, Moser T, Müller M, Opazo F, Outeiro TF, Pape C, Priesemann V, Rehling
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12.08.2024

Morphological correlates of synaptic protein turnover in the mouse brain

Authors Li F, Bahr JN, Bierth FA, Reshetniak S, Tetzlaff C, Fornasiero EF, Wichmann C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2024 Aug 12;7(11):e202402793. Abstract Synaptic proteins need to be replaced regularly, to maintain function and to prevent damage. It is unclear whether this process, known
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02.08.2024

Doubling the resolution of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy

Authors Radmacher N, Nevskyi O, Gallea JI, Thiele JC, Gregor I, Rizzoli SO, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2024). Abstract In this study, we integrate a single-photon detector array into a confocal laser scanning microscope, enabling the combination of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy.
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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11.12.2023

Protein nanobarcodes enable single-step multiplexed fluorescence imaging

Authors de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO Journal PLoS Biology Citation PLoS Biol. 2023 Dec 11;21(12):e3002427. Abstract Multiplexed cellular imaging typically relies on the sequential application of detection probes, as antibodies or DNA
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23.10.2023

Synapsin condensation controls synaptic vesicle sequestering and dynamics

Authors Hoffmann C, Rentsch J, Tsunoyama TA, Chhabra A, Aguilar Perez G, Chowdhury R, Trnka F, Korobeinikov AA, Shaib AH, Ganzella M, Giannone G, Rizzoli SO, Kusumi A, Ewers H, Milovanovic D Journal Nature Communications Citation Nat Commun. 2023 Oct 23;14(1):6730. Abstract Neuronal transmission relies on the regulated secretion of
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13.10.2023

High-resolution analysis of bound Ca2+ in neurons and synapses

Authors Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO Journal Life Science Alliance Citation Life Sci Alliance. 2023 Oct 13;7(1):e202302030. Abstract Calcium (Ca2+) is a well-known second messenger in all cells, and is especially relevant for neuronal activity. Neuronal Ca2+ is found in different forms, with a minority
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05.10.2023

Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry

Authors Roeder SS, Bonnin EA, Wu TD, Guerquin-Kern JL, Jabari S, Brandner S, Eyüpoglu IY, Gollwitzer S, Hamer HM, Gerner ST, Döppner TR, Rummel C, Englund E, Heimke-Brinck R, Borst T, Daniel C, Amann K, Schlötzer-Schrehardt U, Tonchev AB, Roessler K, Schwab S, Bergmann O, Rizzoli SO, Huttner HB Journal
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10.08.2023

Age-dependent structural reorganization of utricular ribbon synapses

Authors Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C Journal Frontiers in Cell and Developmental Biology Citation Front. Cell Dev. Biol., 10 August 2023. Abstract In mammals,
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28.07.2023

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson’s disease

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a
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