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Authors Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P Journal EMBO Reports Citation EMBO Rep. 2020 Jan 7;21(1):e48833. Abstract The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric

Authors Eckermann M, Topperwien M, Robisch AL, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Apr 30;124(17):3482-3493. Abstract Purpose: Recently, progress has been achieved in implementing phase-contrast tomography of soft biological tissues at laboratory sources. This opens up opportunities

Authors Wang H, Farnung L, Dienemann C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020 Jan;27(1):8-13. Abstract Recognition of histone-modified nucleosomes by specific reader domains underlies the regulation of chromatin-associated processes. Whereas structural studies revealed how reader domains bind modified histone peptides, it is

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)

Authors Muhle S, Zhou M, Ghosh A, Enderlein J Journal Physical Review E Citation Phys Rev E. 2019 Nov;100(5-1):052405. Abstract The conformational flexibility and dynamics of unfolded peptide chains is of major interest in the context of protein folding and protein functioning. The rate with which amino acids at different

Authors Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, Schmidt F, Weckbecker D, Linder R, Bender D, Giese A, Pichler BJ, Griesinger C Journal ChemMedChem Citation ChemMedChem. 2020 Mar 5;15(5):411-415. Abstract There is an urgent clinical need for imaging of alpha-synuclein (alphaSyn) fibrils, the hallmark biomarker

Authors Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K Journal European Journal of Heart Failure Citation Eur J Heart

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.

Authors Hillen HS, Bartuli J, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P Journal Cell Citation Cell. 2019 Dec 12;179(7):1525-1536.e12. Abstract Poxviruses use virus-encoded multisubunit RNA polymerases (vRNAPs) and RNA-processing factors to generate m(7)G-capped mRNAs in the host cytoplasm. In the accompanying paper, we report structures

Authors Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U Journal Cell Citation Cell. 2019 Dec 12;179(7):1537-1550.e19. Abstract Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out