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26.11.2025

Nuclear Alpha-Synuclein: Mechanisms and Implications for Synucleinopathies

Authors Outeiro TF, Koss DJ Journal Movement Disorders Citation Mov Disord. 2025 Nov 26. Abstract Alpha-synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson’s disease (PD) and related synucleinopathies. Recent advances reveal
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24.11.2025

Continuous dynamics of cooperation and competition in social decision-making

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal Communications Psychology Citation Commun Psychol. 2025 Nov 24;3(1):170. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games
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24.11.2025

Online jump and kink detection in segmented linear regression: Statistical optimality meets computational efficiency

Authors Hüselitz A, Li H, Munk A Journal Journal of Time Series Analysis Citation Journal of Time Series Analysis 1–22. Abstract We consider the problem of sequential (online) estimation of a single change point in a piecewise linear regression model under a Gaussian setup. We demonstrate that certain CUSUM-type statistics
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24.11.2025

The near-infrared bacteriophytochrome-derived fluorescent protein PENELOPE enables RESOLFT superresolution microscopy

Authors Stumpf D, Jensen N, Mittelheisser C, Keller-Findeisen J, Chizhik AI, Kamper M, Diekmann T, Habenstein F, Jansen I, Enderlein J, Sliwa M, Inamdar K, Hell SW, Jakobs S Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S
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21.11.2025

Phase-separated plasma membranes show elevated viscosity and reduced line tension of liquid-ordered domains

Authors Winkler M, Overhoff K, Skamrahl M, Huynh Huu TT, Teiwes NK, Benten N, Janshoff A, Steinem C Journal Journal of Colloid and Interface Science Citation J Colloid Interface Sci. 2026 Mar 15;706:139549. Abstract Membrane surface viscosity and line tension govern the behavior of lipid domains in plasma membranes and
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20.11.2025

Synphilin-1 modulates alpha-synuclein assembly, release and uptake

Authors Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Nov 20;11(1):326. Abstract Alpha-synuclein (aSyn) is an intrinsically disordered protein involved in phase separation
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18.11.2025

Analysing complex excitation patterns in cardiac tissue using wave event networks

Authors Von Koeller HF, Schlemmer A, Luther S, Döring Y, Voigt N, Parlitz U   Journal Frontiers in Network Physiology   Citation Front Netw Physiol. 2025 Nov 18;5:1674919.   Abstract Cardiac dynamics is governed by complex electrical wave patterns, with disruptions leading to pathological conditions like atrial or ventricular fibrillation.
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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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14.11.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BMC Biology Citation BMC Biol. 2025 Nov 14;23(1):340. Abstract Background: The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the
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13.11.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Müller GF, Roos L, Li J, Göpel T, Weiss KR, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal Nature Biotechnology Citation Nat Biotechnol. 2025 Nov 13. Abstract Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for
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