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29.06.2023

Translation termination in human mitochondria – substrate specificity of mitochondrial release factors

Authors Nadler F, Richter-Dennerlein R Journal Biological Chemistry Citation Biol Chem. 2023 Jun 29. Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to
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29.06.2023

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Authors Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich
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29.06.2023

Mechanisms of inward transmembrane proton translocation

Authors Kovalev K, Tsybrov F, Alekseev A, Shevchenko V, Soloviov D, Siletsky S, Bourenkov G, Agthe M, Nikolova M, von Stetten D, Astashkin R, Bukhdruker S, Chizhov I, Royant A, Kuzmin A, Gushchin I, Rosselli R, Rodriguez-Valera F, Ilyinskiy N, Rogachev A, Borshchevskiy V, Schneider TR, Bamberg E, Gordeliy V
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28.06.2023

Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson’s disease

Authors Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jun 28. Abstract The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to
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28.06.2023

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Authors Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP Journal Chemical Reviews Citation Chem Rev. 2023 Jun 28. Abstract Biomolecular condensates, membrane-less entities arising from liquid-liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions,
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26.06.2023

Structural insights into human co-transcriptional capping

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell. 2023 Jul 20;83(14):2464-2477.e5. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide
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26.06.2023

Statistical analysis of random objects via metric measure Laplacians

Authors Mordant G, Munk A Journal SIAM Journal on Mathematics of Data Science Citation IAM Journal on Mathematics of Data Science 2023 5:2, 528-557 Abstract In this paper, we consider a certain convolutional Laplacian for metric measure spaces and investigate its potential for the statistical analysis of complex objects. The
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21.06.2023

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues

Authors Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger
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20.06.2023

Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans

Authors Guo L, Salian S, Xue JY, Rath N, Rousseau J, Kim H, Ehresmann S, Moosa S, Nakagawa N, Kuroda H, Clayton-Smith J, Wang J, Wang Z, Banka S, Jackson A, Zhang YM, Wei ZJ, Hüning I, Brunet T, Ohashi H, Thomas MF, Bupp C, Miyake N, Matsumoto N, Mendoza-Londono
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16.06.2023

Physiology of intracellular calcium buffering

Authors Eisner D, Neher E, Taschenberger H, Smith G Journal Physiological Reviews Citation Physiol Rev. 2023 Jun 16. Abstract Calcium signalling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is bound to buffers, with typically only about 1% being freely ionized at resting levels in most cells.
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