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22.05.2025

Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture

Authors Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T, Sun S, Birke R, Ilic D, Brose N, Hörnberg H, Lehmann M, Rizzoli SO, Broichhagen J, Lipstein N Journal JACS Au Citation JACS Au 2025. Abstract Synaptic function is governed by highly regulated protein machineries,
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21.05.2025

SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart

Authors Boshnakovska A, Pronto JR, Gall T, Aich A, Prochazka J, Nichtova Z, Sedlacek R, Sobitov I, Ainatzi S, Lenz C, Katschinski DM, Urlaub H, Voigt N, Rehling P, Kremer LS Journal Cell Reports Citation Cell Reports, Volume 44, Issue 6, 115723. Abstract Mitochondria are key to cellular energetics, metabolism,
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20.05.2025

3D imaging of the human temporal bone by X-ray phase-contrast tomography

Authors Schaeper JJ, Tafforeau P, Kampshoff CA, Thomas C, Meyer A, Stadelmann C, Liberman MC, Moser T, Salditt T Journal npj Imaging Citation npj Imaging 3, 21 (2025). Abstract Studying the subtle and intricate three-dimensional structure of the human cochlea embedded in the temporal bone requires structure-preserving imaging approaches with
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16.05.2025

Chronic Vanadium Exposure Promotes Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain

Authors Folarin OR, Olopade FE, Gilbert TT, Ladagu AD, Pires Dos Santos PI, Mustapha OA, Kpasham LZ, Olopade JO, Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2025 May;169(5):e70082. Abstract The interaction of toxic environmental metals and metalloids with brain proteins and polypeptides can result in pathological aggregations and
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15.05.2025

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

Authors Bastille I, Lee L, Moncada-Reid C, Yu WM, Sitko A, Yung A, Zamani M, Christophersen N, Maroofian R, Galehdari H, Babai N, Vona B, Moser T, Goodrich L Journal Cell Reports Citation Cell Rep 2025. accepted manuscript. Abstract Neurons develop diverse synapses that vary in content, morphology, and size.
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13.05.2025

CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K Journal Science Advances Citation Sci Adv. 2025 accepted manuscript.
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12.05.2025

Detection and inference of changes in high-dimensional linear regression with non-sparse structures

Authors Cho H, Kley T, Li H Journal Journal of the Royal Statistical Society, Series B Citation J R Stat Soc Series B: Stat Method. 2025. accepted manuscript. Abstract For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed to be sparse segment-wise, which enables many
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12.05.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BioRxiv Citation bioRxiv 2025.05.08.652815 Abstract The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years evidence has accumulated that connects the synaptic vesicle cluster to the
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11.05.2025

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: Findings from the Rhineland Study

Authors Melas K, Talevi V, Aslam Imtiaz M, Krueger DM, Pena-Centeno T, Fischer A, Aziz NA, Breteler MMB Journal MedRxiv Citation medRxiv 2025.05.09.25327286 Abstract MicroRNAs have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal for cognition and dementia,
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11.05.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Kibédi CZ, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal BioRxiv Citation bioRxiv 2025.05.10.653085 Abstract Our sense of hearing relies
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