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Authors Dijkman PM, Muñoz-García JC, Lavington SR, Kumagai PS, Dos Reis RI, Yin D, Stansfeld PJ, Costa-Filho AJ, Watts A Journal Science Advances Citation Sci Adv. 2020 Aug 14;6(33):eaav8207. Abstract G protein-coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome,

Authors Pape JK, Stephan T, Balzarotti F, Büchner R, Lange F, Riedel D, Jakobs S, Hell SW Journal Proceedings of the National Academy of Sciences Citation PNAS, Aug 2020, 202009364. Abstract The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the

Authors Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2020, 21(16), 5724. Abstract Neurodevelopmental and late-onset neurodegenerative disorders present as separateentities that are clinically and neuropathologically quite distinct. However, recent evidence hashighlighted surprising commonalities

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a

Authors Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF Journal Brain Pathology Citation Brain Pathol. 2020;10.1111/bpa.12890. Abstract Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X‐linked Parkinson’s disease (PD). Physiologically, RAB39B is localized

Authors Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B Journal The Lancet. Neurology Citation The Lancet. Neurology. 2020 Aug;19(8):678-688. Abstract The treatment of multiple sclerosis has been transformed by the successful development of immunotherapies that efficiently reduce disease activity and related clinical relapses during the relapsing-remitting phase of

Authors Raina A, Leite K, Guerin S, Mahajani SU, Chakrabarti KS, Voll D, Becker S, Griesinger C, Bähr M, Kügler S Journal Journal of Neurochemistry Citation J Neurochem. 2020 Jul 30. Abstract A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as

Authors Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T Journal Science Translational Medicine Citation Sci. Transl. Med. 12, eabb8086 (2020). Abstract Cochlear implants provide the brain