Martinez-Sanchez, Antonio

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31.01.2025

Cryo-ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules

Authors Chakraborty S, Martinez-Sanchez A, Beck F, Toro-Nahuelpan M, Hwang IY, Noh KM, Baumeister W, Mahamid J Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Feb 4;122(5):e2404017121. Abstract The functional architecture of the long-lived neuronal
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01.07.2022

MemBrain: A deep learning-aided pipeline for detection of membrane proteins in Cryo-electron tomograms

Authors Lamm L, Righetto RD, Wietrzynski W, Pöge M, Martinez-Sanchez A, Peng T, Engel BD Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Jul 1;224:106990. Abstract Background and objective: Cryo-electron tomography (cryo-ET) is an imaging technique that enables 3D visualization of the native cellular environment
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15.02.2022

Statistical spatial analysis for cryo-electron tomography

Authors Martinez-Sanchez A, Baumeister W, Lučić V Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Feb 15;218:106693.  Abstract Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution.
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21.10.2021

Deep learning improves macromolecule identification in 3D cellular cryo-electron tomograms

Authors Moebel E, Martinez-Sanchez A, Lamm L, Righetto RD, Wietrzynski W, Albert S, Larivière D, Fourmentin E, Pfeffer S, Ortiz J, Baumeister W, Peng T, Engel BD, Kervrann C Journal Nature Methods Citation Nat Methods. 2021 Oct 21. Abstract Cryogenic electron tomography (cryo-ET) visualizes the 3D spatial distribution of macromolecules
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05.03.2021

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

Authors Martinez-Sanchez A, Laugks U, Kochovski Z, Papantoniou C, Zinzula L, Baumeister W, Lučić V Journal Science Advances Citation Sci Adv. 2021 Mar 5;7(10):eabe6204. Abstract   Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported
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