Brose, Nils

Authors Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS Journal eLife Citation eLife 11:e79077. Abstract Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and

Authors Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA Journal PNAS Citation Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2202842119. Abstract The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed

Authors Banerjee A, Imig C, Balakrishnan K, Kershberg L, Lipstein N, Uronen RL, Wang J, Cai X, Benseler F, Rhee JS, Cooper BH, Liu C, Wojcik SM, Brose N, Kaeser PS Journal Neuron Citation Neuron. 2022 Jan 19;110(2):248-265.e9. Abstract Despite the importance of dopamine for striatal circuit function, mechanistic understanding

Authors Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N Journal Neuron Citation Neuron. 2021 Oct 21:S0896-6273(21)00727-3. Abstract During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to release

Authors Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, Cooper BH Journal Neuron Citation Neuron. 2020 Sep 21:S0896-6273(20)30704-2. Abstract Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic membrane-trafficking

Authors Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH Journal Cell Reports Citation Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. Abstract Purpose: Although similar in molecular composition, synapses can exhibit strikingly distinct functional transmitter release and plasticity characteristics. To determine