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April 2026
Arxiv
Distributional Convergence of Empirical Entropic Optimal Transport and Statistical Applications
Arenas-Velilla S, Munk A, Rodríguez LA
April 2026
Physiological Reports
Models of the human heart for biomedical research: Opportunities and challenges
Streckfuss-Bömeke K, Zelarayán LC, Schnabel RB, Kränkel N, Maack C, Eschenhagen T, Kappler HE, Klingmüller U, Kramann R, Loewe A, Milting H, Molina CE, Panáková D, Podesser BK, Schnieke A, Schröder K, Seidel T, Sossalla S, Zgierski-Johnston C, Zimmermann WH, Rog-Zielinska EA, Kohl P
April 2026
medrxiv
Pathogenic desmin variants impair nuclear integrity and drive atrial cardiomyopathy
Su W, van Wijk SW, Kishore P, Huang M, Sultan D, Wijdeveld LFJM, Huiskes FG, Collinet ACT, Voigt N, Liutkute A, Brands M, Kirby T, van der Palen RL, Kurakula K, Ramos KS, Lenz C, Bajema IM, van Spaendonck-Zwarts KY, Brodehl A, Milting H, van Tintelen JP, Brundel BJJM
April 2026
Angewandte Chemie (International ed. in Engl.)
In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation
Du D, Albert L, Weitzel M, Eijsink LE, Cotroneo ER, Marzin D, Opazo F, Simeth NA
April 2026
PLoS Computational Biology
Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies
Sridhar S, Vystrčilová M, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Ecker AS, Gollisch T
April 2026
Cardiovascular Research
Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients
Liutkute A, Berrandou TE, Kestel S, Schnelle M, Dschun O, Amedei HA, Neuenroth L, Rytkin E, Kyshynska O, Kensah G, El-Essawi A, Jebran AF, Danner BC, Baraki H, Kutschka I, Bremmer F, Urlaub H, Schmidt C, Bouatia-Naji N, Efimov IR, Brundel BJJM, Lenz C, Voigt N
April 2026
Cardiovascular Research
Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
Azmain T, Tran DDH, Saifuddin AB, Xu X, Alnour F, Hasenfuß G, Hulshoff M, Eckhardt PL, Tan X, Zeisberg M, Hille SS, Müller OJ, Zeisberg EM
March 2026
PRX Life
Keratin Cortex Stabilizes Cells and Cell-Cell Contacts at High Strains
Meyer R, Unkelbach U, Jain P, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Geisler C, Janshoff A, Köster S
March 2026
medrxiv
FRMPD4, a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss
Liedtke D, Rak K, Schrode KM, Hehlert P, Chamanrou N, Bengl D, Katana R, Heydaran S, Doll J, Han M, Nanda I, Senthilan PR, Jürgens L, Bieniussa L, Voelker J, Neuner C, Hofrichter MAH, Schröder J, Schellens RTW, de Vrieze E, van Wijk E, Zechner U, Herms S, Hoffmann P, Müller T, Dittrich M, Bartsch O, Krawitz PM, Klopocki E, Shehata-Dieler W, Maroofian R, Wang T, Worley PF, Göpfert MC, Galehdari H, Lauer AM, Haaf T, Vona B
March 2026
Journal of Synchrotron Radiation
Fast-scanning small-angle X-ray scattering of hydrated biological cells
Yu B, Sinha M, Da Silva RM, Rölleke U, Burghammer M, Köster S

Authors

Yu B, Sinha M, Da Silva RM, Rölleke U, Burghammer M, Köster S

Journal

Journal of Synchrotron Radiation

Citation

J Synchrotron Radiat. 2026 May 1.

Abstract

Due to their high penetration depth, X-rays enable us to obtain information from the interior of whole unsliced cells. Scanning small-angle X-ray scattering (SAXS), in particular, reveals real-space images in dark-field representation as well as structural information in reciprocal space. However, obtaining information on anisotropy and orientation from cells in an aqueous, close-to-physiological environment remains challenging. Here, we extend the recently introduced fast-scanning SAXS mode with short exposure times of a few milliseconds to such hydrated samples by combining a newly developed X-ray compatible microfluidic chamber and innovative data analysis that includes an effective noise-filtering method. This strategy enables the systematic analysis of radiation damage by quantifying the SAXS signal. Our results demonstrate that scanning SAXS can be used to obtain intracellular information of fixed-hydrated cells and the approach may in the future be applicable to living cells as well.

DOI

10.1107/S1600577526002018
 
Pubmed Link

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