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10.09.2026

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase-nuclease coupling

Authors do Prado PFV, Sharma S, Bhatta A, Vuckovic A, Parvizian Marani M, Llarena David AP, Kuhle B, Hillen HS Journal BioRxiv Citation bioRxiv 2026.09.06.749684. Abstract RNA degradation shapes cellular and organellar gene expression. In human mitochondria, this process is mediated by a dedicated degradosome comprising the helicase SUV3 and
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09.09.2026

Guanosine 10 methylation by TRMT11-TRMT112 optimizes human mitochondrial tRNAs for efficient translation

Authors Petrosyan J, Yilmaz M, Scheitl CPM, Lemus-Diaz N, Boshnakovska A, Tay LLE, Hu W, Beine-Golovchuk O, Touboul D, Richter-Dennerlein R, Höbartner C, Graille M, Rehling P, Bohnsack KE Journal Nucleic Acids Research Citation Nucleic Acids Res. 2026 Aug 24;54(16):gkag859. Abstract Modified nucleotides are essential determinants of RNA function, and
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03.09.2026

Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

Authors Albert L, Basak S, Körner H, Oleksiievets N, Mougios N, Cotroneo ER, Frei MS, Enderlein J, Broichhagen J, Simeth NA, Tsukanov R, Opazo F Journal ACS Nano Citation ACS Nano 2026 Abstract Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when
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03.09.2026

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Authors Quinn CJ, Lahiri SK, Quick AP, Brandenburg S, Uhlenkamp D, Jain A, Moreira LM, Jung SY, Reilly S, Sayeed R, Krasopoulos G, Lehnart SE, Wehrens XHT Journal IJC Heart & Vasculature Citation IJC Heart & Vasculature 66 (2026) 102005. Abstract Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric
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02.09.2026

Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias

Authors Schneider LV, Setya MG, Bao G, Härtter D, Methi A, Krüger D, Schreiber MK, Jensen O, Kanari E, Schmoll KA, Telugu NS, Sakib S, Kim ES, Fahud AL, Novin M, Seedorf A, Diecke S, Fischer A, Liaw NY, Zimmermann WH, Zafeiriou MP Journal Nature Communications Citation Nat Commun. 2026
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