2025

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08.05.2025

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis

Authors Bögershausen N, Cavdarli B, Nagai TH, Milev MP, Wolff A, Mehranfar M, Schmidt J, Choudhary D, Gutiérrez-Gutiérrez Ó, Cyganek L, Saint-Dic D, Zibat A, Köhrer K, Wollenweber TE, Wieczorek D, Altmüller J, Borodina T, Kaçar D, Haliloğlu G, Li Y, Thiel C, Sacher M, Knapik EW, Yigit G, Wollnik
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Dr. Funsho Fakuade, UMG, first author of the study and member of the Hertha Sponer College of the Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC). Photo: MBExC

07.05.2025

Oskar Lapp Research Award 2025 for cardiovascular research goes to Göttingen

Scientists from the ‘Molecular Pharmacology’ working group at the Institute of Pharmacology and Toxicology at the University Medical Center Göttingen (UMG) have been awarded this year’s Oskar Lapp Research Award. Dr. Funsho Fakuade, postdoctoral researcher, and medical students Dominik Hubricht and Vanessa Möller were presented with the award at the
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Magdalena Cöln and Ege Kingir from GRK 2824 give a lecture to students from the Otto Hahn Gymnasium in Göttingen. Photo: Christoph Matthes

06.05.2025

Insights into the connections between “Heart & Brain”

Within the framework of the Research Training Group (RTG) 2824 “Heart & Brain diseases: integrative research across organs”, MBExC member Tobias Brügmann and scientists from the RTG2824 had the exciting opportunity to show students of the Otto-Hahn-Gymnasium (OHG) in Göttingen the fascinating connections between the heart and brain. The session
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05.05.2025

Scattering-based super-resolution optical fluctuation imaging

Authors Yudovich S, Posnjak G, Shani L, Teblum E, Liedl T, Enderlein J, Weiss S Journal Optics Express Citation Opt Express. 2025 May 5;33(9):18824-18842. Abstract Super-resolution optical imaging has become a prominent tool in life and material sciences, allowing one to decipher structures at increasingly greater spatial detail. Among the
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04.05.2025

SarcAsM: AI-based multiscale analysis of sarcomere organization and contractility in cardiomyocytes

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Long J, Tiburcy M, Berecic B, Primeßnig A, Bao G, Cyganek L, Schmidt CF, Zimmermann WH Journal BioRxiv Citation bioRxiv 2025.04.29.650605. Abstract Cardiomyocyte function critically depends on sarcomere dynamics and their organization in myofibrils. To uncover how cardiomyocyte function emerges from
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02.05.2025

Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2025 May 2;21(5):e1013031. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of neural activity. Computational models of the interplay
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The team behind Ovo Labs (from left)- Dr. Agata Zielinska, Prof. Dr. Melina Schuh, and Dr. Oleksandr Yagensky. © Irene Böttcher-Gajewski _ Max Planck Institute for Multidisciplinary Sciences

30.04.2025

Ovo Labs secures 4 million pounds in start-up capital

Founded in January 2025, Ovo Labs is a biotech company that has emerged from the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen (Germany). The company develops novel therapeutics to improve the quality of human eggs. The active compounds are designed to help women remain fertile for longer and
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28.04.2025

Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine

Authors Groshkova MB, Alvanos T, Qi Y, Wang F, Wichmann C, Hua Y, Moser T Journal Frontiers in Cellular Neuroscience Citation Front. Cell. Neurosci., 28 April 2025 Abstract Introduction: Synapses vary greatly in synaptic strength and plasticity, even within the same circuitry or set of pre- and postsynaptic neurons. Neuromodulation
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25.04.2025

Substituent effects in N-acetylated phenylazopyrazole photoswitches

Authors Tovtik R, Marzin D, Weigel P, Crespi S, Simeth NA Journal Beilstein Journals of Organic Chemistry Citation Beilstein J Org Chem. 2025 Apr 25;21:830-838. Abstract Phenylazopyrazole photoswitches proved to be valuable structural motifs for various applications ranging from materials science to medicine. Despite their potential, their structural diversity is
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24.04.2025

World Day for Laboratory Animals

110 scientists clearly affirm their commitment to animal research: “We conduct animal experiments!”   On the occasion of the World Day for Laboratory Animals on 24 April 2025, 110 leading scientists from Germany (including MBExC members) are publicly affirming their commitment to animal research. Under the joint statement “We conduct
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