2025

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10.07.2025

Nucleotide-bound crystal structures of the SARS-CoV-2 helicase NSP13

Authors Kloskowski P, Neumann P, Berndt A, Ficner R Journal Acta Crystallographica Section F-Structural Biology Communications Citation Acta Crystallogr F Struct Biol Commun. 2025 Aug 1. Abstract Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 in ADP- and ATP-bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP-bound model captures
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10.07.2025

Structural basis for no retinal binding in flotillin-associated rhodopsins

Authors Kovalev K, Stetsenko A, Trunk F, Marin E, Haro-Moreno JM, Lamm GHU, Alekseev A, Rodriguez-Valera F, Schneider TR, Wachtveitl J, Guskov A Journal Structure Citation Structure. 2025 Jul 10:S0969-2126(25)00222-9. Abstract Rhodopsins are light-sensitive membrane proteins capturing solar energy via a retinal cofactor covalently attached to a lysine residue. Several
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08.07.2025

FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites

Authors Antonicka H, Vučković A, Weraarpachai W, Hong S, Brischigliaro M, Ahn A, Barrientos A, Hillen HS, Shoubridge EA Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jul 8;53(13):gkaf665. Abstract The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in
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04.07.2025

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Alekseev A, Schellbach AV, Stetsenko A, Haro-Moreno JM, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Rodriguez-Valera F, Wachtveitl J, Guskov A, Kovalev K Journal Science Advances Citation Sci
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03.07.2025

Lamin variants cause cardiac arrhythmogenicity in Drosophila

Authors van Wijk SW, Vree P, Huiskes FG, van der Palen RL, Liutkute A, Voigt N, Wallrath LL, Brundel BJJM Journal Disease Models and Mechanism Citation Dis Model Mech. 2025 Jul 3:dmm.052424. Abstract Atrial fibrillation (AF), the most common progressive cardiac arrhythmia, is associated with serious complications such as stroke
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01.07.2025

Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems

Authors Jakob L, van der Wal JJ, Tovtik R, Copko J, Iagatti A, Donato MD, Crespi S, Simeth NA Journal Chemistry – A European Journal Citation Chemistry. 2025 Jul 1:e202501856. Abstract Photoswitches have been impacting diverse areas of research, introducing means of dynamically regulating their environment through reversible photochemical isomerization.
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Calcium channels of synapses of sensory hair cells couple the sound stimulus to the excitation of the auditory nerve. Compared to the intact CaV1.3 channel (wildtyp, left), the genetically modified CaVAG variant, which is based on a minimal change in the blueprint of the CACNAD1 gene, causes activation of the synapses of sensory hair cells in response to very weak sound stimuli and thus leads to increased auditory nerve activity. The mouse model shows that the increased voltage sensitivity of the channel results in damage to the synapses due to overexcitation even at everyday sound levels. Figure: Karagulyan/Moser.

27.06.2025

Calcium channel in the ear: How a tiny mistake affects hearing

Researchers at the University Medical Center Göttingen (UMG) and the Göttingen Cluster of Excellence “Multiscale Bioimaging” (MBExC) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such as a whisper, are perceived more clearly, but
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Calcium channels of synapses of sensory hair cells couple the sound stimulus to the excitation of the auditory nerve. Compared to the intact CaV1.3 channel (wildtyp, left), the genetically modified CaVAG variant, which is based on a minimal change in the blueprint of the CACNAD1 gene, causes activation of the synapses of sensory hair cells in response to very weak sound stimuli and thus leads to increased auditory nerve activity. The mouse model shows that the increased voltage sensitivity of the channel results in damage to the synapses due to overexcitation even at everyday sound levels. Figure: Karagulyan/Moser.

27.06.2025

Calcium channel in the ear: How a tiny mistake affects hearing

Researchers at the University Medical Center Göttingen (UMG) and the Göttingen Cluster of Excellence “Multiscale Bioimaging” (MBExC) have shown how a minimal change in a single ion channel increases the sensitivity of sensory cells in the inner ear. Even soft sounds, such as a whisper, are perceived more clearly, but
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The organism used to investigate embryonic development: The image shows a top-down view of a fruit fly embryo. In the areas coloured red, cells synchronise their mechanical pulling force. Photo: A. R. Choudhury, M. Häring.

26.06.2025

Listening to each other

Like all complex organisms, every human originates from a single cell that multiplies through countless cell divisions. Thousands of cells coordinate, move and exert mechanical forces on each other as an embryo takes shape. Researchers at the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN), the Max Planck Institute
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The honorands signed their names in the Honorary Degrees Book at the Divinity School before moving to the Sheldonian Theatre. Image: John Cairns/University of Oxford.

25.06.2025

Erwin Neher receives honorary degree by the University of Oxford

On Wednesday 25 June, eight exceptional individuals whose achievements have made lasting contributions to the world were recognised at Oxford University’s Encaenia – an annual ceremony at which honorary degrees are conferred and the University’s benefactors are commemorated.   During the ceremony, degrees were awarded to Sir Mo Farah, MBExC
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