2025

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02.12.2025

Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment

Authors Annamalai K, Dilliker S, Buchholz E, Castro-Hernández R, Panyam N, Pommeranz A, Wiederhake P, Wery von Limont N, Hempel N, Ebner V, Swarnkar S, Mohamed BA, Streckfuss-Bömeke K, Steffens S, Herzig S, Ebert A, Fischer A, Toischer K Journal Cell Communication and Signaling Citation Cell Commun Signal. 2025 Dec
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26.11.2025

Nuclear Alpha-Synuclein: Mechanisms and Implications for Synucleinopathies

Authors Outeiro TF, Koss DJ Journal Movement Disorders Citation Mov Disord. 2025 Nov 26. Abstract Alpha-synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson’s disease (PD) and related synucleinopathies. Recent advances reveal
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24.11.2025

Continuous dynamics of cooperation and competition in social decision-making

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal Communications Psychology Citation Commun Psychol. 2025 Nov 24;3(1):170. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games
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Prof. Dr. Silvio O. Rizzoli, Director of the Institute of Neuro- and Sensory Physiology at UMG, spokesperson of the CRC1286 and BIN at UMG, and member of the MBExC. Photo: umg/swen pförtner

24.11.2025

CRC 1286 enters third funding period

The German Research Foundation (DFG) is funding the Collaborative Research Centre (CRC) 1286 ‘Quantitative Synaptology’ at the University Medical Center Göttingen (UMG) for a further 3.5 years from 1 January 2026. This is already the third round of funding for the research consortium, which was launched in 2017. The total
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24.11.2025

The near-infrared bacteriophytochrome-derived fluorescent protein PENELOPE enables RESOLFT superresolution microscopy

Authors Stumpf D, Jensen N, Mittelheisser C, Keller-Findeisen J, Chizhik AI, Kamper M, Diekmann T, Habenstein F, Jansen I, Enderlein J, Sliwa M, Inamdar K, Hell SW, Jakobs S Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S
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20.11.2025

Synphilin-1 modulates alpha-synuclein assembly, release and uptake

Authors Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Nov 20;11(1):326. Abstract Alpha-synuclein (aSyn) is an intrinsically disordered protein involved in phase separation
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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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14.11.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BMC Biology Citation BMC Biol. 2025 Nov 14;23(1):340. Abstract Background: The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the
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13.11.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Müller GF, Roos L, Li J, Göpel T, Weiss KR, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal Nature Biotechnology Citation Nat Biotechnol. 2025 Nov 13. Abstract Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for
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Cover image of the current issue of the journal Circulation Research: The image shows the regular, blue-stained arrangement of mitochondria in heart muscle cells from the atrium of a patient without cardiac arrhythmia. The cytoskeleton, which supports the structure of the cells and contributes to the orderly organisation of the mitochondria, is shown in magenta. Image: Circulation Research

12.11.2025

Atrial fibrillation: disrupted calcium communication throws the heart out of rhythm

A joint study by Göttingen University Medical Center (UMG) and Würzburg University Hospital provides new insights into why heart muscle cells lose their rhythm in atrial fibrillation. Disrupted calcium communication between central cell structures in the heart could be a decisive mechanism in this process. The findings have been published
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