2025

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04.04.2025

Recent developments in multiple sclerosis neuropathology

Authors Stadelmann C, Franz J, Nessler S Journal Current Opinion in Neurology Citation Curr Opin Neurol. 2025 Apr 4. Abstract Purpose of review: Neuropathological studies in human brain tissue are indispensable for our understanding of disease mechanisms in multiple sclerosis (MS). They inform concepts of lesion evolution, tissue regeneration and
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Prof. Nadja Simeth-Crespi, MBExC member and leader of the Molecular Labeling Chemistry group at the Institute for Organic and Biomolecular Chemistry, University of Göttingen. Photo: MBExC / Swen Pförtner.

03.04.2025

Nadja Simeth-Crespi appointed as W2 professor of Molecular Labeling Chemistry

Congratulations to MBExC member Nadja Simeth-Crespi on her appointment as W2 Professor of Molecular Labeling Chemistry at the University of Göttingen!   Prof. Simeth-Crespi and her team’s research intersects the boundaries of bioorganic and photochemistry, with a focus on the design of smart drugs, biochemical probes and labels, as well
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02.04.2025

Power-law adaptation in the presynaptic vesicle cycle

Authors Mikulasch FA, Georgiev SV, Rudelt L, Rizzoli SO, Priesemann V Journal Communications Biology Citation Commun Biol. 2025 Apr 2;8(1):542. Abstract After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and
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31.03.2025

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Authors Zipf D, Vogt M, Sathyanarayanan U, Wagdi A, Riebeling J, Patejdl R, Bruegmann T Journal Neurogastroenterology and Motility Citation Neurogastroenterol Motil. 2025 Mar 31:e70028. Abstract Background: Optogenetics is a cutting-edge approach that can enable direct stimulation of gastric smooth muscle cells (SMC) by combining cell-specific overexpression of light-sensitive proteins
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31.03.2025

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Authors Solomon PAJ, Budde M, Kohshour MO, Adorjan K, Heilbronner M, Navarro-Flores A, Papiol S, Reich-Erkelenz D, Schulte EC, Senner F, Vogl T, Kaurani L, Krugger DM, Sananbenesi F, Pena T, Burkhardt S, Schutz AL, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Juckel
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Living neurons receive signals from different sources, process them and pass an output signal on to other neurons (left). In the artificial neuron model, this information processing can be described and improved by a learning objective (right). Similar to their biological models, this independent learning allows novel artificial neurons to solve tasks in a self-organized way. Photo: Andreas Schneider

28.03.2025

Artificial neurons organize themselves

Göttingen research team constructs network of self-learning infomorphic neurons   Novel artificial neurons learn independently and are more strongly modeled on their biological counterparts. A team of researchers from the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN) at the University of Göttingen and the Max Planck Institute for
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27.03.2025

Junior Fellow (f/m/d)

The Multiscale Bioimaging Cluster of Excellence (MBExC) of the University Medical Center Göttingen is looking for a new position for the earliest start date. Junior Fellow (f/m/d) full time, with 38,5 hours per week, initially available for 1 year, continuation for further 3 years pending MBExC renewal Remuneration according to
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27.03.2025

Understanding mitochondrial protein import: a revised model of the presequence translocase

Authors Jain N, Chacinska A, Rehling P Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2025 Mar 27:S0968-0004(25)00050-7. Abstract Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial
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26.03.2025

The inner nuclear layer in pediatric multiple sclerosis

Authors Hummel-Abmeier H, Naxer S, Kadas EM, Zimmermann H, Knaack B, Huppke P, Kowallick A, Meier K, Brandt AU, Paul F, Schittkowski M, Oertel FC, Gärtner J Journal Neurology: Neuroimmunology and Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2025 May;12(3):e200387. Abstract Background and objectives: Pediatric onset multiple sclerosis (POMS) leads to optic
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26.03.2025

Microtubules as a versatile reference standard for expansion microscopy

Authors Chowdhury R, Mimoso T, Chouaib AA, Mougios N, Krah D, Opazo F, Köster S, Rizzoli SO, Shaib AH Journal Communications Biology Citation Commun Biol. 2025 Mar 26;8(1):499. Abstract Expansion microscopy (ExM) is continually improving, and new ExM variants need to be validated on well-defined biological structures. There is no
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