2024

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The first and last authors of the study in front of the heart research building of the University Medical Center Göttingen (from left to right): Dominik Hubricht, medical student; Dr Fleur Mason, postdoctoral researcher; Vanessa Möller, medical student; Dr Funsho Fakuade, postdoctoral researcher and Prof Dr Niels Voigt, Professor of Molecular Pharmacology at the Institute of Pharmacology and Toxicology. Photo: Julia Szikszay

10.09.2024

Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation

Impaired calcium buffering in heart muscle cells promotes the progression and perpetuation of atrial fibrillation. This was discovered by researchers from the Heart Center of the University Medical Center Göttingen (UMG) and the German Centre for Cardiovascular Research (DZHK). The findings offer potential starting points for new therapies. The results
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10.09.2024

KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Authors Tapia Contreras C, Falke JD, Seifert DM, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi
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09.09.2024

Rational approximation of golden angles: Accelerated reconstructions for radial MRI

Authors Scholand N, Schaten P, Graf C, Mackner D, Holme HCM, Blumenthal M, Mao A, Assländer J, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2024 Sep 9. Abstract Purpose: To develop a generic radial sampling scheme that combines the advantages of golden ratio sampling with simplicity
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03.09.2024

Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry

Authors Welp LM, Wulf A, Chernev A, Horokhovskyi Y, Moshkovskii S, Dybkov O, Neumann P, Pašen M, Siraj A, Raabe M, Göthert H, Walshe JL, Infante DA, Schwarzer ACdAP,Dickmanns A, Johannsson S, Schmitzova J, Wohlgemuth I, Netz E, He Y, Fritzemeier K, Delanghe B, Viner R, Vos SM, Oberbeckmann E,
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03.09.2024

Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina

Authors Krüppel S, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Zapp SJ, Mietsch M, Karamanlis D, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2024 Sep 3;20(9):e1012370. Abstract Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed by the retina.
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01.09.2024

Optimistic Search: Change Point Estimation for Large-scale Data via Adaptive Logarithmic Queries

Authors Kovacs S, Li H, Haubner L, Munk A, Buhlmann P Journal Journal of Machine Learning Research Citation J Mach Learn Res 25(297):1−64, 2024. Abstract Change point estimation is often formulated as a search for the maximum of a gain function describing improved fits when segmenting the data. Searching one
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31.08.2024

The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish

Authors Bornhorst D, Hejjaji AV, Steuter L, Woodhead NM, Maier P, Gentile A, Alhajkadour A, Santis Larrain O, Weber M, Kikhi K, Guenther S, Huisken J, Tamplin OJ, Stainier DYR, Gunawan F Journal Nature Communications Citation Nat Commun. 2024 Aug 31;15(1):7589. Abstract The contribution of endocardial cells (EdCs) to the
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Falko Mohrs, Minister of Science and Culture of Lower Saxony, with Prof. Dr. Urs Valentin Nägerl, Director of the Institute of Anatomy and Cell Biology at the UMG and first “Lower Saxony Professorship”, and Prof. Dr. Wolfgang Brück, Director of Research and Teaching and Spokesman of the Board of Directors of the UMG. Photo: umg/spförtner

30.08.2024

First “Lower Saxony Professorship” goes to the University Medical Center Göttingen

MBExC member Prof. Dr. Urs Valentin Nägerl, Director of the Institute of Anatomy and Cell Biology at the University Medical Center Göttingen (UMG) since 1 September 2024, has been awarded the first “Lower Saxony Professorship”. The funding line of the Lower Saxony Ministry of Science and Culture and the Volkswagen
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29.08.2024

Blood-derived microRNAs are related to cognitive domains in the general population

Authors Melas K, Talevi V, Imtiaz MA, Etteldorf R, Estrada S, Krüger DM, Pena-Centeno T, Aziz NA, Fischer A, Breteler MMB Journal Alzheimer’s & Dementia Citation Alzheimers Dement. 2024 Aug 29. Abstract Introduction: Blood-derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous
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29.08.2024

Bleaching protection and axial sectioning in fluorescence nanoscopy through two-photon activation at 515 nm

Authors Bredfeldt JE, Oracz J, Kiszka KA, Moosmayer T, Weber M, Sahl SJ, Hell SW Journal Nature Communications Citation Nat Commun. 2024 Aug 29;15(1):7472. Abstract Activation of caged fluorophores in microscopy has mostly relied on the absorption of a single ultraviolet (UV) photon of ≲400 nm wavelength or on the simultaneous
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