2024

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10.03.2024

3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes

Authors Pochechueva TV, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, Lehnart SE Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2024 Mar 10;25(6):3183. Abstract We present novel workflows for Q-FISH nanoscopy with the potential for prognostic applications and resolving novel chromatin compaction changes. DNA-fluorescence
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10.03.2024

Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies

Authors Sridhar S, Vystrčilová M, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Ecker A, Gollisch T Journal BioRxiv Citation bioRxiv 2024.03.05.583449. Abstract Retinal ganglion cells, the output neurons of the vertebrate retina, often display nonlinear summation of visual signals over their receptive fields.
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09.03.2024

Convolutional neural network models of the primate retina reveal adaptation to natural stimulus statistics

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2024.03.06.583740. Abstract The diverse nature of visual environments demands that the retina, the first stage of the visual system, encodes a vast range of stimuli with various statistics. The retina adapts its computations to some
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08.03.2024

Else Kröner Fresenius Center for Optogenetic Therapies approved

Else Kröner-Fresenius-Stiftung (EKFS) supports new research center for optogenetic therapies with 37.4 million euros over ten years at the University Medical Center Göttingen (UMG). The state of Lower Saxony is strongly supporting the establishment of the center and, together with the UMG, is holding out the prospect of up to
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f.l.t.r. Prof. Madeja, Chairman EKFS Management Board; F. Mohrs, Lower Saxony's Minister Science & Culture; Prof. Brück, Dean Medical Faculty; Dr. Dangmann, Member EKFS Management Board; Prof. Moser, Auditory Neuroscience UMG. Photo: UMG/spförtner

08.03.2024

Else Kröner Fresenius Center for Optogenetic Therapies approved

Else Kröner-Fresenius-Stiftung (EKFS) supports new research center for optogenetic therapies with 37.4 million euros over ten years at the University Medical Center Göttingen (UMG). The state of Lower Saxony is strongly supporting the establishment of the center and, together with the UMG, is holding out the prospect of up to
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08.03.2024

Synphilin-1 as a modulator of aSyn assembly

Authors Lázaro DF, Amen T, Gerhardt E, Santos PI, Milovanovic D, Höglinger G, Outeiro TF Journal BioRxiv Citation bioRxiv 2024.03.05.583522. Abstract Alpha-synuclein (aSyn) is an intrinsically disordered protein that undergoes phase-separation and is associated with several neurodegenerative conditions. However, the function and the pathological role of aSyn are still elusive.
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06.03.2024

Towards a biological diagnosis of PD

Authors Chopra A, Lang AE, Höglinger G, Outeiro TF Journal Parkinsonism & Related Disorders Citation Parkinsonism Relat Disord. 2024 Mar 6:106078. Abstract Since the original description by James Parkinson, Parkinson’s disease (PD) has intrigued us for over 200 years. PD is a progressive condition that is incurable so far, and
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Prof. Dr. Timo Betz (Photo: UMG/SPförtner)

02.03.2024

First heat map for individual red blood cells

Researchers measure heat flow: from active metabolic forces inside cell to flickering cell membrane   Entropy is often associated with disorder and chaos, but in biology it is related to energy efficiency and is closely linked to metabolism, the set of chemical reactions that sustain life. An international research team
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The image shows a high-resolution 3D model of the plant RNA polymerase PEP, which plays a central role in photosynthesis. Copyright: Paula Favoretti Vital do Prado and Johannes Pauly / MPI-NAT, UMG

01.03.2024

Light into the darkness of photosynthesis: 3D insights into the copying machine of chloroplasts

For life on Earth, it is essential that plants carry out photosynthesis and ultimately produce oxygen and chemical energy with the help of sunlight. Researchers from Göttingen and Hannover have now succeeded for the first time in visualizing the copying machine of chloroplasts, the RNA polymerase PEP, in high-resolution 3D.
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The image shows a high-resolution 3D model of the plant RNA polymerase PEP, which plays a central role in photosynthesis. Copyright: Paula Favoretti Vital do Prado and Johannes Pauly / MPI-NAT, UMG

01.03.2024

Light into the darkness of photosynthesis: 3D insights into the copying machine of chloroplasts

• A molecular 3D snapshot of the copying machine in chloroplasts, the RNA polymerase PEP, provides new insights into the evolution and function of plant photosynthesis. • Using a cryo-electron microscope, a high-resolution image of a 19-subunit PEP complex from white mustard (Sinapis alba) was taken. • Evolutionary analyses indicate
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