2024

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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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In the research laboratory: (from left to right) Prof. Dr. Metin Tolan, President of the University of Göttingen, Falko Mohrs, Minister for Science and Culture of Lower Saxony, Prof. Dr. Claudia Steinem, Deputy Spokesperson of the MBExC and Professor at the Faculty of Chemistry at the University of Göttingen, Prof. Dr Wolfgang Brück, Spokesperson of the Board of Directors and Director of Research and Teaching at the University Medical Center Göttingen (UMG), and Prof. Dr. Emilie Macé, Professor of Dynamics of Excitable Cell Networks at the Center for Biostructural Imaging of Neurodegeneration (BIN). Photo: umg/spförtner

22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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22.03.2024

Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures

Authors Shvachiy L, Amaro-Leal Â, Machado F, Rocha I, Outeiro TF, Geraldes V Journal Biomedicines Citation Biomedicines. 2024 Mar 22;12(4):711. Abstract Lead exposure is a significant health concern, ranking among the top 10 most harmful substances for humans. There are no safe levels of lead exposure, and it affects multiple
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20.03.2024

[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brain

Authors Saw RS, Buss S, Schmidt F, Ryazanov S, Leonov A, Kuebler L, Bleher D, Papadopoulos I, Roeben B, Schmidt F, Reimold M, Bonanno F, Grotegerd AK, Ruf V, Dahl B, Sandiego C, Henry K, Fehrenbacher B, Schaller M, Kahle P, Gasser T, Brockmann K, Reischl G, la Fougère C,
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20.03.2024

METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway

Authors Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y   Journal Cell Death & Disease   Citation Cell Death Dis 15, 229 (2024).   Abstract Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging
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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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19.03.2024

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Authors Morici M, Gabrielli S, Fujiwara K, Paternoga H, Beckert B, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2432.   Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to
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19.03.2024

Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose

Authors Lamtar Mohammadi EL, Keikha R, Outeiro TF, Jebali A   Journal Cellulose   Citation Cellulose (2024)   Abstract Interfering with the aggregation of the protein alpha-synuclein (aSyn) has been a topic of research for > 25 years, as this protein is found in pathognomonic protein aggregates in the brain of
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Preparing the heart patch for the surgery. Photo: UKSH

18.03.2024

Two years with heart patch: patient reports on experiences

Unique in the world: laboratory-grown heart tissue has been implanted in patients with heart failure as part of a study conducted by the University Medical Center Göttingen (UMG) and the University Hospital Schleswig-Holstein (UKSH). The so-called heart patch is intended to strengthen the heart permanently and has the potential for
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17.03.2024

Multiscale Quantile Regression with Local Error Control

Authors Liu Z, Li H   Journal Arxiv   Citation arXiv:2403.11356.   Abstract For robust and efficient detection of change points, we introduce a novel methodology MUSCLE (multiscale quantile segmentation controlling local error) that partitions serial data into multiple segments, each sharing a common quantile. It leverages multiple tests for
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