2024

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30.05.2024

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

Authors Bode D, Pronto JRD, Schiattarella GG, Voigt N Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 May 30. Abstract Atrial fibrillation (AF) is a continually growing health-care burden that often presents together with metabolic disorders, including diabetes mellitus and obesity. Current treatments often fall short of preventing AF
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29.05.2024

Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

Authors Muenker TM, Vos BE, Betz T Journal eLife Citation eLife13:RP97416. Abstract Living cells are complex entities that perform many different complex tasks with astonishing robustness. While the direct dependence of biological processes on controlled protein expression is well established, we only begin to understand how intracellular mechanical characteristics guide
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Directors of the selected DZKJ partner sites (from left to right): Prof. Dr. Klaus-Michael Debatin (Ulm and Deputy Spokesperson DZKJ), Prof. Dr. Neeltje van den Berg (Greifswald/Rostock), Prof. Dr. Antje Körner (Leipzig/Dresden), Prof. Dr. Christoph Klein (Munich), Prof. Dr. Ania Muntau (Hamburg), Prof. Dr. Marcus Mall (Berlin), Prof. Dr. Jutta Gärtner (Göttingen and Spokesperson DZKJ). Photo: UMG/Simone Schröder

29.05.2024

DZKJ enters the start-up phase

German Centre for Child and Adolescent Health (DZKJ) will become a new partner of the German Centres for Health Research (DZG) from 1 June 2024. The nationally organised and networked research centre will receive 30 million euros in funding from the Federal Ministry of Education and Research during the two-year
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29.05.2024

3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing

Authors Reichmann J, Sarrazin C, Schmale S, Blaurock C, Balkema-Buschmann A, Schmitzer B, Salditt T Journal Scientific Reports Citation Sci Rep 14, 12348 (2024). Abstract X-ray Phase Contrast Tomography (XPCT) based on wavefield propagation has been established as a high resolution three-dimensional (3D) imaging modality, suitable to reconstruct the intricate
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28.05.2024

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Authors Reichmann J, Franz J, Eckermann M, Schulz K, Mollenhauer B, Stadelmann C, Salditt T   Journal MedRxiv   Citation medRxiv 2024.03.26.24304193.   Abstract This study leverages X-ray Phase-Contrast Tomography (XPCT) for detailed analysis of neurodegenerative diseases like Alzheimer’s and Parkinson’s, focusing on the 3D visualization and quantification of neuropathological
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27.05.2024

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Authors Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A Journal Cells Citation Cells. 2024 May 27;13(11):923. Abstract Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic
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27.05.2024

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the
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23.05.2024

CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent
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22.05.2024

The molecular machinery for maturation of primary mtDNA transcripts

Authors Vučković A, Freyer C, Wredenberg A, Hillen HS Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R19-R25. Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs). Mitochondrial transcription produces long, polycistronic transcripts that
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22.05.2024

Coordinating mitochondrial translation with assembly of the OXPHOS complexes

Authors Kremer LS, Rehling P Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R47-R52. Abstract The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are
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