2024

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Directors of the selected DZKJ partner sites (from left to right): Prof. Dr. Klaus-Michael Debatin (Ulm and Deputy Spokesperson DZKJ), Prof. Dr. Neeltje van den Berg (Greifswald/Rostock), Prof. Dr. Antje Körner (Leipzig/Dresden), Prof. Dr. Christoph Klein (Munich), Prof. Dr. Ania Muntau (Hamburg), Prof. Dr. Marcus Mall (Berlin), Prof. Dr. Jutta Gärtner (Göttingen and Spokesperson DZKJ). Photo: UMG/Simone Schröder

29.05.2024

DZKJ enters the start-up phase

German Centre for Child and Adolescent Health (DZKJ) will become a new partner of the German Centres for Health Research (DZG) from 1 June 2024. The nationally organised and networked research centre will receive 30 million euros in funding from the Federal Ministry of Education and Research during the two-year
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29.05.2024

3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing

Authors Reichmann J, Sarrazin C, Schmale S, Blaurock C, Balkema-Buschmann A, Schmitzer B, Salditt T Journal Scientific Reports Citation Sci Rep 14, 12348 (2024). Abstract X-ray Phase Contrast Tomography (XPCT) based on wavefield propagation has been established as a high resolution three-dimensional (3D) imaging modality, suitable to reconstruct the intricate
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27.05.2024

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Authors Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A Journal Cells Citation Cells. 2024 May 27;13(11):923. Abstract Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic
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27.05.2024

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the
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23.05.2024

CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent
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22.05.2024

The molecular machinery for maturation of primary mtDNA transcripts

Authors Vučković A, Freyer C, Wredenberg A, Hillen HS Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R19-R25. Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs). Mitochondrial transcription produces long, polycistronic transcripts that
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22.05.2024

Coordinating mitochondrial translation with assembly of the OXPHOS complexes

Authors Kremer LS, Rehling P Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R47-R52. Abstract The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are
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21.05.2024

GestaltMatcher Database – A global reference for facial phenotypic variability in rare human diseases

Authors Lesmann H, Hustinx A, Moosa S, Klinkhammer H, Marchi E, Caro P, Abdelrazek IM, Pantel JT, Ten Hagen M, Thong MK, Binti Mazlan RA, Tae SK, Kamphans T, Meiswinkel W, Li JM, Javanmardi B, Knaus A, Uwineza A, Knopp C, Tkemaladze T, Elbracht M, Mattern L, Jamra RA, Velmans
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19.05.2024

Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain

Authors Herwerth M, Wyss MT, Schmid NB, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Stadelmann C, Misgeld T, Bennett JL, Saab AS, Jessberger S, Weber B Journal BioRxiv Citation bioRxiv 2024.05.18.594292. Abstract Mature astrocytes become activated upon non-specific tissue damage and contribute to glial
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16.05.2024

Autophagy preferentially degrades non-fibrillar polyQ aggregates

Authors Zhao DY, Bäuerlein FJB, Saha I, Hartl FU, Baumeister W, Wilfling F Journal Molecular Cell Citation Mol Cell. 2024 May 16;84(10):1980-1994.e8. Abstract Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington’s disease (HD). Huntingtin (Htt), the
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