2023

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25.08.2023

Modular architecture facilitates noise-driven control of synchrony in neuronal networks

Authors Yamamoto H, Spitzner FP, Takemuro T, Buendía V, Murota H, Morante C, Konno T, Sato S, Hirano-Iwata A, Levina A, Priesemann V, Muñoz MA, Zierenberg J, Soriano J Journal Science Advances Citation Sci Adv. 2023 Aug 25;9(34):eade1755. Abstract High-level information processing in the mammalian cortex requires both segregated processing
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22.08.2023

Ethanol-Induced Atrial Fibrillation Results From Late INa and Can Be Prevented by Ranolazine

Authors Mustroph J, Baier MJ, Unsin D, Provaznik Z, Kozakov K, Lebek S, Tarnowski D, Schildt S, Voigt N, Wagner S, Maier LS, Neef S Journal Circulation Citation Circulation. 2023 Aug 22;148(8):698-700. Abstract No abstract available. DOI 10.1161/CIRCULATIONAHA.123.064561   Pubmed Link
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19.08.2023

Bioengineering of a human innervated cardiac muscle model

Authors Schneider LV, Bao G, Methi A, Jensen O, Schmoll KA, Setya MG, Sakib MS, Fahud AL, Brockmoeller J, Fischer A, Liaw NY, Zimmermann WH, Zafeiriou MP Journal BioRxiv Citation bioRxiv 2023.08.18.552653. Abstract Cardiac autonomic neurons control cardiac contractility. Dysregulation of the autonomic nervous system can lead to sympathetic overdrive
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Prof. Dr. Wolfram Hubertus Zimmermann, Director of the Institute of Pharmacology and Toxicology at the University Medical Center Göttingen and scientific director of the BioVAT-HF-DZHK20 study. Photo: MBExC / spförtner

18.08.2023

SPRIND live podcast event with Wolfram Zimmermann

The Federal Agency for Disruptive Innovation SPRIND in collaboration with Life Science Factory will host a live podcast event with MBExC member Wolfram Zimmermann from the University Medical Center Göttingen (UMG) on 6 September 2023 at 4 pm at the Life Science Factory in Göttingen. The program includes two 30-minute
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18.08.2023

A scalable clustering algorithm to approximate graph cuts

Authors Suchan L, Li H, Munk A Journal Arxiv Citation arXiv:2308.09613. Abstract Due to its computational complexity, graph cuts for cluster detection and identification are used mostly in the form of convex relaxations. We propose to utilize the original graph cuts such as Ratio, Normalized or Cheeger Cut in order
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18.08.2023

DNA-Based Optical Sensors for Forces in Cytoskeletal Networks

Authors Jayachandran C, Ghosh A, Prabhune M, Bath J, Turberfield AJ, Hauke L, Enderlein J, Rehfeldt F, Schmidt CF Journal ACS Applied Nano Materials Citation ACS Appl. Nano Mater. 2023. Abstract Mechanical forces are relevant for many biological processes, from wound healing and tumor formation to cell migration and differentiation.
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18.08.2023

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Authors Sant’Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D Journal Molecular Medicine Citation Mol Med. 2023 Aug 18;29(1):111. Abstract Background: Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to
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16.08.2023

A viral ADP-ribosyltransferase attaches RNA chains to host proteins

Authors Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K Journal Nature Citation Nature. 2023 Aug 16. Abstract The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When
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MBExC member André Fischer, Director at the German Center for Neurodegenerative Diseases (DZNE) site Göttingen, interviewed by Hertha Sponer College member Svilen Georgiev from the Institute of Neuro- and Sensory Physiology at the UMG. Source: "Neuroscience and Beyond", Youtube.

15.08.2023

New “Neuroscience and Beyond” episode with André Fischer

In the new episode of “Neuroscience and Beyond” MBExC member André Fischer, Director at the German Center for Neurodegenerative Diseases (DZNE) site Göttingen and Professor at the Department for Psychiatry and Psychotherapy, University Medical Center Göttingen (UMG) talks about “Alzheimer’s disease and Epigenetics”. The focus of this interview is on
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10.08.2023

Age-dependent structural reorganization of utricular ribbon synapses

Authors Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C Journal Frontiers in Cell and Developmental Biology Citation Front. Cell Dev. Biol., 10 August 2023. Abstract In mammals,
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