2023

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17.02.2023

Molecular engineering to enhance reactivity and selectivity in an ultrafast photoclick reaction

Authors Fu Y, Simeth NA, Toyoda R, Brilmayer R, Szymanski W, Feringa BL   Journal Angewandte Chemie International Edition   Citation Angew Chem Int Ed Engl. 2023 Feb 17:e202218203.   Abstract Light-induced 9,10-phenanthrenequinone-electron-rich alkene (PQ-ERA) photocycloadditions are an attractive new type of photoclick reaction, featuring fast conversions and high biocompatibility.
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15.02.2023

Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency

Authors Schlotawa L, Tyka K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregula J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J   Journal EMBO Molecular Medicine   Citation
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11.02.2023

Association of early life stress and cognitive performance in patients with schizophrenia and healthy controls

Authors Senner F, Schneider-Axmann T, Kaurani L, Zimmermann J, Wiltfang J, von Hagen M, Vogl T, Spitzer C, Senner S, Schulte EC, Schmauß M, Schaupp SK, Reimer J, Reich-Erkelenz D, Papiol S, Kohshour MO, Lang FU, Konrad C, Kirchner SK, Kalman JL, Juckel G, Heilbronner M, Heilbronner U, Figge C,
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08.02.2023

NFATc1 is a central mediator of EGFR-induced ARID1A chromatin dissociation during acinar cell reprogramming

Authors Zhang Z, Wang X, Hamdan FH, Likhobabina A, Patil S, Aperdannier L, Sen M, Traub J, Neesse A, Fischer A, Papantonis A, Singh SK, Ellenrieder V, Johnsen SA, Hessmann E Journal Cellular and Molecular Gastroenterology and hepatology Citation Cell Mol Gastroenterol Hepatol. 2023 Feb 7:S2352-345X(23)00018-8. Abstract Background & aims:
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06.02.2023

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

Authors Antoniou A, Auderset L, Kaurani L, Sebastian E, Zeng Y, Allahham M, Cases-Cunillera S, Schoch S, Gruendemann J, Fischer A, Schneider A   Journal Cell Reports   Citation Cell Rep. 2023 Feb 6;42(2):112063.   Abstract Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the
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02.02.2023

Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytes

Authors Harasimov K, Uraji J, Mönnich EU, Holubcová Z, Elder K, Blayney M, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2023 Feb 2. Abstract Accurate chromosome segregation during meiosis is crucial for reproduction. Human and porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly
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02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
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01.02.2023

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise
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Prof. Dr. Rubén Fernández-Busnadiego, University Medical Center (Photo: MBExC) Figure: 3D rendering of a cryo-electron tomogram of a peripheral nerve. (Reproduced from https://www.biorxiv.org/content/10.1101/2021.04.14.437159)

31.01.2023

European funding for Rubén Fernández Busnadiego

Expert in cryo-electron microscopy at the University Medical Center Göttingen receives Consolidator Grant of the European Research Council to investigate the membrane architecture of nerve cells and its pathological alterations in axonopathies. (mbexc/umg) Prof. Dr. Rubén Fernández Busnadiego from the Institute for Neuropathology at the University Medical Center Göttingen (UMG)
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Prof. Dr. Rubén Fernández-Busnadiego, University Medical Center (Photo: MBExC) Figure: 3D rendering of a cryo-electron tomogram of a peripheral nerve. (Reproduced from https://www.biorxiv.org/content/10.1101/2021.04.14.437159)

31.01.2023

European funding for Rubén Fernández Busnadiego

Rubén Fernández Busnadiego, expert in cryo-electron microscopy at the University Medical Center Göttingen (UMG) and member of the MBExC received a Consolidator Grant of the European Research Council (ERC). The ERC supports his research project ”In situ structural basis of human axonopathies“ (“cryoNERVE“) over five years with a total of
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