2022

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Two images of the "World of Senses" exhibition 2022: The organ of Corti of the inner ear with outer and inner hair cells (cyan) and some of the synaptically connected neurons that form the afferent auditory nerve (red / white). Image: Christian Vogl, UMG, and Benjamin Cooper, MPI-NAT. (left) Light microscopic 3D reconstruction of a dye-filled neuron (grey) and its dendritic arborizations acquired from the brain of a mouse. Image: Albrecht Sigler and Benjamin Cooper, MPI-NAT. (right)

01.09.2022

New „World of Senses” Exhibition 2022

New fascinating images from the “World of Senses” exhibition (part 2) were shown from in the main entrance hall of the University Medical Center Göttingen from the end of June to the end of August 2022. Here you find the UMG clip about the current exhibition: Watch this video on
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01.09.2022

From guide to guard-activation mechanism of the stress-sensing chaperone Get3

Authors Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U Journal Molecular Cell Citation Mol Cell. 2022 Sep 1;82(17):3226-3238.e7. Abstract Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved yeast protein, Get3, switches
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01.09.2022

Structure of angiogenin dimer bound to double-stranded RNA

Authors Sievers K, Ficner R Journal Acta Crystallographica Section F-Structural Biology Communications Citation Acta Crystallogr F Struct Biol Commun. 2022 Sep 1;78(Pt 9):330-337. Abstract Angiogenin is an unusual member of the RNase A family and is of great interest in multiple pathological contexts. Although it has been assigned various regulatory
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26.08.2022

Multiscale architecture: Mechanics of composite cytoskeletal networks

Authors Lorenz C, Köster S Journal Biophysics Reviews Citation Biophysics Rev. 3, 031304 (2022) Abstract Different types of biological cells respond differently to mechanical stresses, and these responses are mainly governed by the cytoskeleton. The main components of this biopolymer network are actin filaments, microtubules, and intermediate filaments, whose mechanical
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25.08.2022

Combined optical fluorescence microscopy and X-ray tomography reveals substructures in cell nuclei in 3D

Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the
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23.08.2022

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species

Authors Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel
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22.08.2022

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
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18.08.2022

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming

Authors Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW Journal Star Protocols Citation STAR Protoc. 2022 Aug 18;3(3):101560. Abstract The methods for the culture and cardiomyocyte differentiation of human embryonic stem cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex and
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Two images of the "World of Senses" exhibition 2022: The organ of Corti of the inner ear with outer and inner hair cells (cyan) and some of the synaptically connected neurons that form the afferent auditory nerve (red / white). Image: Christian Vogl, UMG, and Benjamin Cooper, MPI-NAT. (left) Light microscopic 3D reconstruction of a dye-filled neuron (grey) and its dendritic arborizations acquired from the brain of a mouse. Image: Albrecht Sigler and Benjamin Cooper, MPI-NAT. (right)

18.08.2022

Exhibition „World of Senses” at the UMG

The fascinating images from this year’s “World of Senses” exhibition will be on display in the main entrance hall of the University Medical Center Göttingen until 25 August 2022. The exhibition provides special insights into the wonderful world of senses at the cellular level of sensory cells and neurons from
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Prof. Dr. med. Tobias Moser, Director of the Institute for Auditory Neuroscience Göttingen, UMG. Photo: MBExC / spförtner

16.08.2022

Tobias Moser among Falling Walls Life Sciences Winners 2022

Tobias Moser is one of ten winners of Falling Walls 2022 in the category Life Sciences. The Falling Walls Foundation annually selects top projects worldwide that shape the future of science and society. An international jury acknowledged the outstanding quality and relevance of his research on understanding and restoration of
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