2022

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12.12.2022

Mono- and Intralink Filter (Mi-Filter) To Reduce False Identifications in Cross-Linking Mass Spectrometry Data

Authors Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F Journal Analytical Chemistry Citation Anal. Chem. 2022, 94, 51, 17751–17756. Abstract Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However,
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09.12.2022

Free-Breathing Liver Fat, R*2 and B0 Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-based Reconstruction

Authors Tan Z, Unterberg-Buchwald C, Blumenthal M, Scholand N, Schaten P, Holme C, Wang X, Raddatz D, Uecker M   Journal IEEE Transactions on Medical Imaging   Citation IEEE Trans Med Imaging. 2022 Dec 9;PP. Abstract This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition.
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08.12.2022

Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

Authors Galbusera R, Bahn E, Weigel M, Schaedelin S, Franz J, Lu PJ, Barakovic M, Melie-Garcia L, Dechent P, Lutti A, Sati P, Reich DS, Nair G, Brück W, Kappos L, Stadelmann C, Granziera C. Journal Brain Pathology Citation Brain Pathol. 2022 Dec 8:e13136. Abstract Quantitative MRI (qMRI) probes the
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07.12.2022

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in
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06.12.2022

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation

Authors Voigt N, Maack C, Pronto JRD Journal Journal of the American College of Cardiology Citation J Am Coll Cardiol. 2022 Dec, 80 (23) 2220–2223. Abstract No abstract available DOI 10.1016/j.jacc.2022.09.043   Pubmed Link
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29.11.2022

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

Authors Pinheiro Neto J, Spitzner FP, Priesemann V Journal PLoS Computational Biology Citation PLoS Comput Biol 18(11): e1010678. Abstract To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity
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Prof. Dr. Markus Bohnsack (Photo: UMG/SPförtner)

25.11.2022

New CRC 1565 at University Medical Center Göttingen

The German Research Foundation (DFG) is funding a new Collaborative Research Center (SFB) led by the University Medical Center Göttingen (UMG) starting January 2023. The new CRC 1565, entitled “Molecular mechanisms and interplay of gene expression processes”, will receive 10 million euros for an initial funding period of four years.
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Prof. Dr. Hauke Hillen (Photo: UMG/SPförtner)

25.11.2022

New member of the EMBO Young Investigator Programme

As one of 24 young investigators, MBExC member Prof. Dr. Hauke Hillen is elected as a new member of the EMBO Young Investigator Programme. The programme supports excellent group leaders who have been in independent positions for less than four years and have an excellent track record of scientific achievements.
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24.11.2022

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.
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23.11.2022

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.
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