August

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26.08.2022

Multiscale architecture: Mechanics of composite cytoskeletal networks

Authors Lorenz C, Köster S Journal Biophysics Reviews Citation Biophysics Rev. 3, 031304 (2022) Abstract Different types of biological cells respond differently to mechanical stresses, and these responses are mainly governed by the cytoskeleton. The main components of this biopolymer network are actin filaments, microtubules, and intermediate filaments, whose mechanical
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25.08.2022

Combined optical fluorescence microscopy and X-ray tomography reveals substructures in cell nuclei in 3D

Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the
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23.08.2022

JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species

Authors Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel
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22.08.2022

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Authors Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci., 22 August 2022. Abstract Fluoride has been used in the
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18.08.2022

A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming

Authors Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW Journal Star Protocols Citation STAR Protoc. 2022 Aug 18;3(3):101560. Abstract The methods for the culture and cardiomyocyte differentiation of human embryonic stem cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex and
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Two images of the "World of Senses" exhibition 2022: The organ of Corti of the inner ear with outer and inner hair cells (cyan) and some of the synaptically connected neurons that form the afferent auditory nerve (red / white). Image: Christian Vogl, UMG, and Benjamin Cooper, MPI-NAT. (left) Light microscopic 3D reconstruction of a dye-filled neuron (grey) and its dendritic arborizations acquired from the brain of a mouse. Image: Albrecht Sigler and Benjamin Cooper, MPI-NAT. (right)

18.08.2022

Exhibition „World of Senses” at the UMG

The fascinating images from this year’s “World of Senses” exhibition will be on display in the main entrance hall of the University Medical Center Göttingen until 25 August 2022. The exhibition provides special insights into the wonderful world of senses at the cellular level of sensory cells and neurons from
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Prof. Dr. med. Tobias Moser, Director of the Institute for Auditory Neuroscience Göttingen, UMG. Photo: MBExC / spförtner

16.08.2022

Tobias Moser among Falling Walls Life Sciences Winners 2022

Tobias Moser is one of ten winners of Falling Walls 2022 in the category Life Sciences. The Falling Walls Foundation annually selects top projects worldwide that shape the future of science and society. An international jury acknowledged the outstanding quality and relevance of his research on understanding and restoration of
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Left: Concept drawing of combination of optical cochlear implant (oCI) with gene therapy product (top), close-up of waveguide-based oCI prototype for excitation with red light (bottom). Middle: Top view of the cochlea. Optical excitation of the neurons allows specific areas of the cochlea to be targeted for excitation. Right: Cross-section through the cochlea. Source: Keppeler/Moser (UMG)

12.08.2022

State of Lower Saxony promotes the preclinical development of the optical cochlear implant

The state of Lower Saxony and the Volkswagen Foundation approve funding for scientists at the UMG and the MBExC Cluster of Excellence of about 1 milion euros of the “SPRUNG” (formerly: “Niedersächsisches Vorab”). The team around Tobias Moser focuses on the development of the optical cochlear implant for the restoration
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Left: Concept drawing of combination of optical cochlear implant (oCI) with gene therapy product (top), close-up of waveguide-based oCI prototype for excitation with red light (bottom). Middle: Top view of the cochlea. Optical excitation of the neurons allows specific areas of the cochlea to be targeted for excitation. Right: Cross-section through the cochlea. Source: Keppeler/Moser (UMG)

12.08.2022

State of Lower Saxony promotes the preclinical development of the optical cochlear implant

The state of Lower Saxony and the Volkswagen Foundation approve funding for scientists of the UMG and the MBExC Cluster of Excellence of about 1 milion euros of the “SPRUNG” (formerly: “Niedersächsisches Vorab”) for the development of the optical cochlear implant for the restoration of hearing in humans. (umg/mbexc) Hearing
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09.08.2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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