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Photo: User of an classical cochlea implant (CI) in front of an optical CI with optical fibre in blue. Courtesy: F. El May, M. Zerche, UMG/MBExC.

20.05.2022

The first light-controlled drug that could improve the hearing of people with cochlear implants

Researchers at the University Medical Center Göttingen and the Institute for Bioengineering of Catalonia in Spain have succeeded for the first time worldwide, in stimulating hearing in vivo by light without the need for genetic manipulation. This new light-controlled drug, capable of triggering the neural pathways involved in hearing, can
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Prof. Dr. Hauke Hillen, Junior Professor at the Department of Cellular Biochemistry, University Medical Center Göttingen (UMG) and group leader at the Max Planck Institute (MPI) for Multidisciplinary Sciences. Photo: mpi-nat/irene böttcher-gajewski

19.05.2022

Hauke Hillen receives Peter and Traudl Engelhorn Research Award 2022

The Peter and Traudl Engelhorn Foundation awards MBExC member Prof. Dr. Hauke Hillen for his work on the molecular mechanisms of gene activation of viruses and mitochondria. The Peter and Traudl Engelhorn Research Award is endowed with 10,000 euros. Link to the press release of the UMG (in German)
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18.05.2022

Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea

Authors Garrido-Charles A, Huet AT, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P Journal Journal of the American Chemical Society Citation J Am Chem Soc. 2022 May 18. Abstract Artificial control of neuronal activity enables studies of neural circuits and restoration of neural function. Direct, rapid,
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17.05.2022

Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory

Authors Dombrowski M, Engeholm M, Dienemann C, Dodonova, S. Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol 29, 493–501 (2022). Abstract Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here,
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14.05.2022

Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways

Authors Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 May 14:ddac104. Abstract Parkinson’s disease (PD) is a neurological disorder with complex interindividual etiology that is
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Professor Sarah Köster Photo: Göttingen University / Klein und Neumann, Iserlohn

12.05.2022

Interdisciplinary PhDs in biological physics

The German Research Foundation (DFG) will in future fund a new Research Training Group (RTG) in biological physics at Göttingen University. A total of 25 PhD students and one data scientist will thus receive financial support for their structured training in an interdisciplinary field of physics. The Research Training Group
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11.05.2022

How Junctophilins organize electrically excitable cells

Experts from the University Medical Center Göttingen and the Baylor College of Medicine in Houston, Texas, summarize 20 years of Junctophilin research, new molecular analyses, and the role of Junctophilins in the development of human diseases in a comprehensive in-depth review article. Published with Spotlight Cover in the renowned journal
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Graphical illustration of the roles of junctophilin in normal tissues and molecular alterations in junctophilins associated with muscle, cardiac and neuronal diseases. Spotlight Cover, Physiol Rev.

11.05.2022

How Junctophilins organize electrically excitable cells

Experts from the University Medical Center Göttingen and the Baylor College of Medicine in Houston, Texas, summarize 20 years of Junctophilin research, new molecular analyses, and the role of Junctophilins in the development of human diseases in a comprehensive in-depth review article. Published with Spotlight Cover in the renowned journal
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10.05.2022

Science back in Touch with Society – face-to-face Summer Events 2022

This summer, the MBExC will again be present at several public events to engage and inspire people about its pioneering heart and brain research.   June , 10-12, 2022: Tag der Niedersachsen (Hannover) The MBExC will present several exhibits to to present its fascinating multiscale heart & brain research and
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05.05.2022

Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

Authors Bali B, Gruber-Dujardin E, Kusch K, Rankovic V, Moser T Journal Life Science Alliance Citation Life Sci Alliance. 2022 May 5;5(8):e202101338 Abstract AAV-mediated optogenetic neural stimulation has become a clinical approach for restoring function in sensory disorders and feasibility for hearing restoration has been indicated in rodents. Nonetheless, long-term
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