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08.03.2021

The vesicle cluster as a major organizer of synaptic composition in the short-term and long-term

Authors Reshetniak S, Rizzoli SO Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2021 Mar 8;71:63-68. Abstract For decades, the synaptic vesicle cluster has been thought of as a storage space for synaptic vesicles, whose obvious function is to provide vesicles for the depolarization-induced release of neurotransmitters;
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05.03.2021

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

Authors Martinez-Sanchez A, Laugks U, Kochovski Z, Papantoniou C, Zinzula L, Baumeister W, Lučić V Journal Science Advances Citation Sci Adv. 2021 Mar 5;7(10):eabe6204. Abstract   Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported
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In the cochlea of the inner ear, sound waves are detected in a frequency-specific manner and subsequently transmitted to the brain. Image @ Christian Vogl, Carlos Duque Afonso, Tobias Moser, Institute for Auditory Neuroscience, UMG, 2017.

03.03.2021

Radio broadcast on the World Hearing Day

On the World Hearing Day, Prof. Dr. Dirk Beutner from the Department of Otorhinolaryngology, UMG Göttingen and Dr. Marcus Jeschke from the Cognitive Hearing in Primates group at the German Primate Center and UMG are talking about hearing at the Stadtradio Göttingen broadcast “Mittendrin”, organized by the MBExC in collaboration
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03.03.2021

An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

Authors Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C, Llabrés S Journal Biochimica et Biophysica Acta – Biomembranes Citation Biochim Biophys Acta Biomembr. 2021 Mar 3:183601. Abstract Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross the
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01.03.2021

Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity

Authors Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB Journal Frontiers in Aging Neuroscience Citation Front Aging Neurosci. 2021 Mar 22;13:635760. Abstract Tauopathies are neurodegenerative disorders with increasing incidence
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01.03.2021

Molecular and cellular dynamics of the 26S proteasome

Authors Sakata E, Eisele MR, Baumeister W Journal Biochimica et Biophysica Acta – Proteins and Proteomics Citation Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. Epub 2020 Dec 13. Abstract In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome
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