2021

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31.12.2021

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

Authors Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P Journal Elife Citation Elife. 2021 Dec 31;10:e68213. Abstract Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system
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22.12.2021

Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis

Authors Barbarics B, Eildermann K, Kaderali L, Cyganek L, Plessmann U, Bodemeyer J, Paul T, Ströbel P, Urlaub H, Tirilomis T, Lenz C, Bohnenberger H. Journal Scientific Reports Citation Sci Rep. 2021 Dec 22;11(1):24389. Abstract Aortic valve stenosis (AVS) is one of the most common valve diseases in the world.
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21.12.2021

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

Authors Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I Journal Life Science Alliance Citation Life Sci Alliance. 2021 Dec 21;5(3):e202101185. Abstract The autophagy-lysosomal pathway is impaired
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21.12.2021

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

Authors Reichardt M, Moller Jensen P, Andersen Dahl V, Dahl AB, Ackermann M, Shah H, Länger F, Werlein C, Kuehnel MP, Jonigk D, Salditt T Journal Elife Citation eLife 2021;10:e71359. Abstract For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue
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20.12.2021

Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors

Authors Nadlera F, Lavdovskaiaa E, Richter-Dennerlein R Journal RNA Biology Citation RNA Biol. 2021 Dec 20;1-15. Abstract The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13
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15.12.2021

Super-resolution imaging: when biophysics meets nanophotonics

Authors Koenderink AF, Tsukanov R, Enderlein J, Izeddin I, Krachmalnicoff V Journal Nanophotonics Citation Nanophotonics, vol. 11, no. 2, 2022, pp. 169-202. Abstract Probing light–matter interaction at the nanometer scale is one of the most fascinating topics of modern optics. Its importance is underlined by the large span of fields
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UMG Compatibility Award 2021

UMG Compatibility Award 2021 (from left): Prof. Dr. Wolfgang Brück (Chairman of the UMG Executive Board), award winner Prof. Dr. Christine Stadelmann-Nessler (Director of the Institute of Neuropathology, UMG) and Anja Lipschik (UMG, Head of the Equal Opportunities Office). Photo: umg/spförtner

14.12.2021

UMG Compatibility Prize 2021 awarded to Christine Stadelmann-Nessler

Prof. Dr. Christine Stadelmann-Nessler, Director of the Institute of Neuropathology and MBExC member, receives the UMG Compatibility Award 2021. She particularly supports employees with family and care responsibilities. The “UMG Compatibility Award” stands for commitment to improving working conditions for employees with family responsibilities. Link to the press release of
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09.12.2021

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Authors Wegener JW, Wagdi A, Wagner E, Katschinski DM, Hasenfuss G, Bruegmann T, Lehnart SE Journal Frontiers in Physiology Citation Front Physiol. 2021 Dec 9;12:777770. Abstract Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop
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Dr. Tal Dankovich, first author of the publication and Postdoc at the Institute of Neuro- and Sensory Physiology, UMG. Photo: Medienservice MPI for Biophysical Chemistry (P. Goldmann) Visualization of the extra-cellular matrix in cultured neurons. Source: Dr. Tal Dankovich, UMG.

Left: Dr. Tal Dankovich, first author of the publication and Postdoc at the Institute of Neuro- and Sensory Physiology, UMG. Photo: Medienservice MPI for Biophysical Chemistry (P. Goldmann) Right: Visualization of the extra-cellular matrix in cultured neurons. Source: Dr. Tal Dankovich, UMG.

08.12.2021

How matrix recycling keeps the brain flexible

Scientists of the Cluster of Excellence Multiscale Bioimaging describe a new mechanism that supports synaptic plasticity in the adult brain. Published in Nature Communications. The extracellular matrix (ECM) gives cell assemblies their structure and plays an important role in cell communication and control. In the adult brain, it forms lattices
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Dr. Tal Dankovich, first author of the publication and Postdoc at the Institute of Neuro- and Sensory Physiology, UMG. Photo: Medienservice MPI for Biophysical Chemistry (P. Goldmann) Visualization of the extra-cellular matrix in cultured neurons. Source: Dr. Tal Dankovich, UMG.

Left: Dr. Tal Dankovich, first author of the publication and Postdoc at the Institute of Neuro- and Sensory Physiology, UMG. Photo: Medienservice MPI for Biophysical Chemistry (P. Goldmann) Right: Visualization of the extra-cellular matrix in cultured neurons. Source: Dr. Tal Dankovich, UMG.

08.12.2021

How matrix recycling keeps the brain flexible

Scientists of the Cluster of Excellence Multiscale Bioimaging describe a new mechanism that supports synaptic plasticity in the adult brain. Published in Nature Communications. The extracellular matrix (ECM) gives cell assemblies their structure and plays an important role in cell communication and control. In the adult brain, it forms lattices
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