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14.08.2020

Conformational dynamics of a G protein-coupled receptor helix 8 in lipid membranes

Authors Dijkman PM, Muñoz-García JC, Lavington SR, Kumagai PS, Dos Reis RI, Yin D, Stansfeld PJ, Costa-Filho AJ, Watts A Journal Science Advances Citation Sci Adv. 2020 Aug 14;6(33):eaav8207. Abstract G protein-coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome,
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11.08.2020

Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins

Authors Pape JK, Stephan T, Balzarotti F, Büchner R, Lange F, Riedel D, Jakobs S, Hell SW Journal Proceedings of the National Academy of Sciences Citation PNAS, Aug 2020, 202009364. Abstract The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the
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Multi-color 3D MINFLUX nanoscopy visualizes the cellular distribution and relative position of proteins that are only a few nanometers apart. The picture shows a mitochondrion from a human skin cell in which two proteins in the inner mitochondrial membrane are stained: A subunit of the MICOS complex (Mic60), is colored in orange, a subunit of the mitochondrial ATP synthase (ATPB), is colored in blue. The scale bar has a length of 500 nanometers.© Till Stephan & Jasmin Pape / Max Planck Institute for Biophysical Chemistry

11.08.2020

Dissecting protein assemblies

In an initial application of the powerful MINFLUX nanoscopy technique to cell biology, researchers led by Stefan Hell and Stefan Jakobs have now optically dissected the distribution of individual proteins in a ~ 20-nanometer-sized protein cluster within a cellular organelle in 3D using multiple colors. MINFLUX nanoscopy thus proves to
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10.08.2020

The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

Authors Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2020, 21(16), 5724. Abstract Neurodevelopmental and late-onset neurodegenerative disorders present as separateentities that are clinically and neuropathologically quite distinct. However, recent evidence hashighlighted surprising commonalities
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10.08.2020

Reliable estimation of membrane curvature for cryo-electron tomography

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a
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06.08.2020

RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies

Authors Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF Journal Brain Pathology Citation Brain Pathol. 2020;10.1111/bpa.12890. Abstract Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X‐linked Parkinson’s disease (PD). Physiologically, RAB39B is localized
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CRISPR/Cas9-repaired iPSC-cardiomyocytes display a restored function and a normalized muscle contraction.© Cyganek, UMG

05.08.2020

CRISPR/Cas9 – GENE EDITING: New therapeutic approach for congenital heart defects

Scientists at the Heart Center of the University Medical Center Göttingen have for the first time found an approach for a personalised therapy option with “gene editing” for the Noonan Syndrome. Publication in the renowned journal “Circulation“. Link to the press release
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CRISPR/Cas9-repaired iPSC-cardiomyocytes display a restored function and a normalized muscle contraction.© Cyganek, UMG

05.08.2020

CRISPR/Cas9 – GENE EDITING: New therapeutic approach for congenital heart defects

Scientists at the Heart Center of the University Medical Center Göttingen have for the first time found an approach for a personalised therapy option with “gene editing” for the Noonan Syndrome. Publication in the renowned journal “Circulation“. (umg/ mbexc) Congenital heart diseases are the most common organ defects. They occur
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01.08.2020

Remyelination in multiple sclerosis: from basic science to clinical translation

Authors Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B Journal The Lancet. Neurology Citation The Lancet. Neurology. 2020 Aug;19(8):678-688. Abstract The treatment of multiple sclerosis has been transformed by the successful development of immunotherapies that efficiently reduce disease activity and related clinical relapses during the relapsing-remitting phase of
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