Urlaub, Henning

Authors Kraxner J, Lorenz C, Menzel J, Parfentev I, Silbern I, Denz M, Urlaub H, Schwappach B, Köster S Journal Nanoscale Citation Nanoscale. 2020 Dec 22. Abstract The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments

Authors Lavdovskaia E, Denks K, Nadler F, Steube E, Linden A, Urlaub H, Rodnina MV, Richter-Dennerlein R Journal Nucleic Acids Research Citation Nucleic Acids Res. 2020 Dec 2;gkaa1132. Abstract Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure rapid and accurate synthesis of mitochondrial proteins. Defects in translation

Authors Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, Deckers M, Rehling P Journal FEBS Letters Citation FEBS Lett. 2020 Oct 30. Abstract The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The Translocase of the Inner

Authors Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, Lenz C, Urlaub H, Mori M, Ottmann C, Shattock MJ, Lehnart SE, Schwappach B Journal Science Signaling Citation Sci Signal. 2020 Sep 1;13(647):eaaz1436. Abstract The cardiac membrane protein phospholamban (PLN) is targeted by protein kinase A (PKA)

Authors Vos SM, Farnung L, Linden A, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020. Abstract Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We previously reported an activated porcine Pol II elongation complex, EC*, encompassing

Authors Parfentev I, Schilbach S, Cramer P, Urlaub H Journal Journal of Proteomics Citation J Proteomics. 2020 May 30;220:103754. Abstract Cross-linking mass spectrometry (XL-MS) is steadily expanding its range of applications from purified protein complexes to more complex samples like organelles and even entire cells. One main challenge using non-cleavable

Authors Linden A, Deckers M, Parfentev I, Pflanz R, Homberg B, Neumann P, Ficner R, Rehling P, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2020 Apr 24;mcp.RA120.002028. Abstract Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is currently receiving much attention. Not only

Authors Wagner FR, Dienemann C, Wang H, Stützer A, Tegunov D, Urlaub H, Cramer P Journal Nature Citation Nature 579, 448–451 (2020). Abstract Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs). In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)

Authors Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U Journal Cell Citation Cell. 2019 Dec 12;179(7):1537-1550.e19. Abstract Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out