Urlaub, Henning

Authors Kokic G, Wagner FR, Chernev A, Urlaub H, Cramer P Journal Nature Citation Nature 2021 Abstract Transcription-coupled DNA repair removes bulky DNA lesions from the genome and protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits

Authors Sievers K, Welp L, Urlaub H, Ficner R Journal RNA Biology Citation RNA Biol. 2021 Jul 31:1-15. Abstract The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr. While both subunits of the functional heterodimer have been crystallized individually,

Authors Chen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer P Journal Molecular Cell Citation Molecular Cell (2021). In press. Abstract The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here,

Authors Helm MS, Dankovich TM, Mandad S, Rammer B, Jähne S, Salimi V, Koerbs C, Leibrandt R, Urlaub H, Schikorski T, Rizzoli SO Journal Nature Neuroscience Citation Nat Neurosci (2021). Abstract Dendritic spines, the postsynaptic compartments of excitatory neurotransmission, have different shapes classified from ‘stubby’ to ‘mushroom-like’. Whereas mushroom spines

Authors Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2021 Jun 16;12(1):3672. Abstract Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC)

Authors Martinez Hernandez A, Silbern I, Geffers I, Tatenhorst L, Becker S, Urlaub H, Zweckstetter M, Griesinger C, Eichele G Journal Frontiers in Neuroscience Citation Front Neurosci. 2021 Jun 17;15:643391. Abstract α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease

Authors Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, Urlaub H, Cramer P Journal Journal of Biological Chemistry Citation J Biol Chem. 2021 Apr 29:100734. Abstract The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex Mediator, which regulates gene transcription by RNA

Authors Silbern I, Pan KT, Fiosins M, Bonn S, Rizzoli SO, Fornasiero EF, Urlaub H, Jahn R Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2021 Feb 11:100061. Abstract Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming

Authors Zheng X, Zhang L, Kuang Y, Venkataramani V, Jin F, Hein K, Zafeiriou MP, Lenz C, Moebius W, Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann WH, Bähr M, Doeppner TR  Journal Translational Stroke Research Citation Transl. Stroke Res. 12, 185–203 (2021). Abstract Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs

Authors Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JR, Sutanto H, Pacheu Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuβ G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener JW, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE Journal Circulation Research Citation