Urlaub, Henning

Authors Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA Journal Biology of Reproduction Citation Biol Reprod. 2023 Sep 29:ioad130. Abstract In response to luteinizing hormone, multiple proteins in rat and mouse granulosa cells are rapidly dephosphorylated, but the responsible phosphatases remain to be identified.

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex

Authors Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K Journal Nature Citation Nature. 2023 Aug 16. Abstract The mechanisms by which viruses hijack the genetic machinery of the cells they infect are of current interest. When

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a

Authors Garg G, Dienemann C, Farnung L, Schwarz J, Linden A, Urlaub H, Cramer P Journal Molecular Cell Citation Mol Cell. 2023 Jul 20;83(14):2464-2477.e5. Abstract Co-transcriptional capping of the nascent pre-mRNA 5′ end prevents degradation of RNA polymerase (Pol) II transcripts and suppresses the innate immune response. Here, we provide

Authors Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A Journal Circulation Research Citation Circ Res. 2023 Jun 14.

Authors Schmitzová J, Cretu C, Dienemann C, Urlaub H, Pena V Journal Nature Citation Nature. 2023 May 10. Abstract Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact

Authors Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2022;12(8):2397-2422. Abstract Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.

Authors Wang H, Schilbach S, Ninov M, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 21. Abstract The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed