Rizzoli, Silvio

Authors Dankovich TM, Rizzoli SO Journal iScience Citation iScience. 2021 Feb 3;24(3):102134. Abstract Optical super-resolution microscopy (SRM) has enabled biologists to visualize cellular structures with near-molecular resolution, giving unprecedented access to details about the amounts, sizes and spatial distributions of macromolecules in the cell. Precisely quantifying these molecular details requires

Authors Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO Journal BMC Molecular and Cell Biology Citation BMC Mol and Cell Biol 22, 5 (2021). Abstract Background Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these

Authors Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanovic D, Rizzoli S, Köster S Journal Scientific Reports Citation Sci Rep 10, 21086 (2020). Abstract Protein dynamics in the synaptic bouton are still not well understood, despite many quantitative studies of synaptic structure and function. The complexity of the synaptic

Authors Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2020 Oct 2;21(19):E7298. Abstract Synapses play a central role for the processing of information in the brain and have been analyzed in countless biochemical, electrophysiological, imaging, and computational

Authors Bonnin EA, Rizzoli SO Journal Frontiers in Behavioral Neuroscience Citation Front Behav Neurosci. 2020 Jul 20;14:124. Abstract The behavior of an animal has substantial effects on its metabolism. Such effects, including changes in the lipid composition of different organs, or changes in the turnover of the proteins, have typically

Authors Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli S Journal EMBO Journal Citation EMBO J. 2020 Jul 6;e104596. Abstract Many proteins involved in synaptic transmission are well known, and their features, as their abundance or spatial distribution, have been analyzed

Authors Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, Becker S, Rizzoli SO, Basmanav FB, Opazo F Journal Nature Communications Citation Nat Commun. 2020 Jun 1;11(1):2729. Abstract Aggregation and spreading of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, thus monitoring human αSyn (hαSyn) in animal models or cell cultures is vital for the field. However,

Authors Sograte-Idrissi S, Schlichthaerle T, Duque-Afonso CJ, Alevra M, Strauss S, Moser T, Jungmann R, Rizzoli SO, Opazo F Journal Nanoscale Citation Nanoscale. 2020 May 14;12(18):10226-10239. Abstract A standard procedure to study cellular elements is via immunostaining followed by optical imaging. This methodology typically requires target-specific primary antibodies (1.Abs), which

Authors Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH Journal Cell Reports Citation Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. Abstract Purpose: Although similar in molecular composition, synapses can exhibit strikingly distinct functional transmitter release and plasticity characteristics. To determine

Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs