2024

Home >> Publications >> Release Date >> 2024 >> Seite 19
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28.01.2024

Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line

Authors Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2024 Jan 28;75:103317. Abstract Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal
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26.01.2024

High throughput methods for cardiac cellular electrophysiology studies: The road to personalized medicine

Authors Seibertz F, Voigt N Journal American Journal of Physiology: Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jan 26. Abstract Personalized medicine refers to the tailored application of medical treatment at an individual level, taking into account the specific genotype or phenotype of each patient
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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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24.01.2024

Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions

Authors Bloothooft M, Verbruggen B, Seibertz F, van der Heyden MAG, Voigt N, de Boer TP Journal Frontiers in Physiology Citation Front Physiol. 2024 Jan 24;15:1298340. Abstract Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately
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24.01.2024

Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes

Authors Schmidt J, Kaulfuß S, Ott H, Gaubert M, Reintjes N, Bremmer F, Dreha-Kulaczewski S, Stroebel P, Yigit G, Wollnik B Journal Human Genetics Citation Hum Genet. 2024 Jan 24. Abstract The fibroblast growth factor receptors comprise a family of related but individually distinct tyrosine kinase receptors. Within this family,
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22.01.2024

Drosophila MIC10b can polymerize into cristae-shaping filaments

Authors Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S Journal Life Science Alliance Citation Life Sci Alliance. 2024 Jan 22;7(4):e202302177. Abstract Cristae are invaginations of the mitochondrial inner membrane
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22.01.2024

Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants

Authors Knauer C, Haltern H, Schoger E, Kügler S, Roos L, Zelarayán LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal Molecular Therapy: Nucleic Acids Citation Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. Abstract Gene variants in LZTR1 are implicated to cause Noonan syndrome associated with a severe and
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17.01.2024

Metal-induced energy transfer (MIET) Imaging of cell surface engineering with multivalent DNA nanobrushes

Authors Wang DX, Liu B, Han GM, Kong DM, Enderlein J, Chen T Journal ACS Nano Citation ACS Nano. 2024 Jan 17. Abstract The spacing between cells has a significant impact on cell–cell interactions, which are critical to the fate and function of both individual cells and multicellular organisms. However,
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13.01.2024

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise

Authors Methi A, Islam MR, Kaurani L, Sakib MS, Krueger DM, Pena T, Burkhardt S, Liebetanz D, Fischer A Journal Molecular Neurobiology Citation Mol Neurobiol. 2024 Jan 13. Abstract Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region
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10.01.2024

Folate receptor α deficiency – Myelin-sensitive MRI as a reliable biomarker to monitor the efficacy and long-term outcome of a new therapeutic approach

Authors Dreha-Kulaczewski S, Sahoo P, Preusse M, Gkalimani I, Dechent P, Helms G, Hofer S, Steinfeld R, Gärtner J Journal Journal of Inherited Metabolic Disease Citation J Inherit Metab Dis. 2024 Mar;47(2):387-403. Abstract Cerebral folate transport deficiency, caused by a genetic defect in folate receptor α, is a devastating neurometabolic
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